Synthesis and characterization of nano-hydroxyapatite/graphene oxide composite materials for medical implant coating applications

Kaviya, M.; Ramakrishnan, Praveen; Mohamed, S. Beer; Ramakrishnan, Ramprasath; Gimbun, Jolius; Veerabadran, K.M.; Kuppusamy, M. R.; Kaviyarasu, K.; Sridhar, T.

doi:10.1016/j.matpr.2020.02.932

Cited by 33 publications

(13 citation statements)

References 23 publications

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“…Hydroxyapatite's properties and applicability can be enhanced by developing different composite materials, in order to achieve superior behavior in biomedical applications. Nano-hydroxyapatite/graphene oxide, as a potential composite material for medical implant coating applications, gained Kaviya and coworkers' attention due to graphene oxide chemical and mechanical stability, magnetic behavior, thermal and electrical conductivity [28]. The synthesis of the composite material, using water as a mixture media, presented better morphological characteristics for the targeted application than those obtained in alcoholic media (flaky texture reflecting its layered microstructure), thus proposing water as a proper solvent, instead of toxic organic solvents.…”

Section: Coating Materials For Biomedical Applicationsmentioning

confidence: 99%

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Fierăscu

Chican

2021

Coatings

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In recent decades, coating materials have gained researchers’ interest, finding applications in different areas such as antimicrobial coatings for biomedical applications, coatings for increasing the shelf-life of commercial products, or coatings for the conservation of cultural heritage artifacts. The use of new types of coating materials based on natural ingredients can lead to the removal of harmful chemicals and contribute to the development of materials having different and promising properties. New challenges can appear both in the production process, as well as in the case of final application, when coating materials must be applied on various supports. The present review paper aims to be a critical discussion regarding the possibility of using natural ingredients as functional coatings, and to prove that the same material can be used in different fields, from the biomedical to environmental, or from cultural heritage protection to the food and cosmetic industries. The paper is based on the newest published studies, and its main goal is to be an inspiration source for researchers, in order to create more functional and applicable composite coatings in specific fields.

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Section: Coating Materials For Biomedical Applicationsmentioning

confidence: 99%

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Fierăscu

Chican

2021

Coatings

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“…Earlier, the plasma-sprayed HA coating was thick and rough, which resulted in clinical failures and cracking; however, new physical deposition and chemical techniques facilitated the deposition of thinner (100 nm) CaP/HA coatings having an accelerated and increased bone formation [37,219]. Similarly, organic implant nanocoatings comprising proteins, growth factors, polysaccharides, and drugs were incorporated into the latticework of CaP and HA for numerous therapeutic properties [173,215,217].…”

Section: Biomimetic and Bioactive Coatingsmentioning

confidence: 99%

“…Several organic and inorganic molecules have been reported to provide enhanced bioactive nanocoating bonds on the implant and bone interface ( Table 2). It is well documented in the literature that the micron/submicron-scale surface roughness enhances osseointegration through osteoblast differentiation [58,115,173]. Moreover, Gittens et al suggested that the combination of micro-/submicron-scale roughness along with nanoscale structures in vivo improves osteoblast differentiation to indicate the potential for improved implant osseointegration [149].…”

Section: Biomimetic and Bioactive Coatingsmentioning

confidence: 99%

Customized Therapeutic Surface Coatings for Dental Implants

et al. 2020

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Dental implants are frequently used to support fixed or removable dental prostheses to replace missing teeth. The clinical success of titanium dental implants is owed to the exceptional biocompatibility and osseointegration with the bone. Therefore, the enhanced therapeutic effectiveness of dental implants had always been preferred. Several concepts for implant coating and local drug delivery had been developed during the last decades. A drug is generally released by diffusion-controlled, solvent-controlled, and chemical controlled methods. Although a range of surface modifications and coatings (antimicrobial, bioactive, therapeutic drugs) have been explored for dental implants, it is still a long way from designing sophisticated therapeutic implant surfaces to achieve the specific needs of dental patients. The present article reviews various interdisciplinary aspects of surface coatings on dental implants from the perspectives of biomaterials, coatings, drug release, and related therapeutic effects. Additionally, the various types of implant coatings, localized drug release from coatings, and how released agents influence the bone–implant surface interface characteristics are discussed. This paper also highlights several strategies for local drug delivery and their limitations in dental implant coatings as some of these concepts are yet to be applied in clinical settings due to the specific requirements of individual patients.

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“…Hydroxyapatite is the most stable calcium phosphate ceramic material regarding temperature, pH and composition of intravascular fluid. 49 …”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite is the most stable calcium phosphate ceramic material regarding temperature, pH and composition of intravascular fluid. 49 Aside from its advantages, hydroxyapatite has poor mechanical strength which limits its broad application, especially as an implant material. 77 The mechanical properties of pure hydroxyapatite are in the range of 120-150 MPa, 38-300 MPa and 38-250 MPa for compressive, tensile and bending strength.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Halim¹,

Hussein²,

Kandar

2021

IJN

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Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.

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Synthesis and characterization of nano-hydroxyapatite/graphene oxide composite materials for medical implant coating applications

Cited by 33 publications

References 23 publications

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Customized Therapeutic Surface Coatings for Dental Implants

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

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