Synthesis and characterization of nano-hydroxyapatite in maltodextrin matrix

Abstract

In this study, we report the direct precipitation of nano-HA in the present of maltodextrins with the different dextrose equivalent (DE) values in the range of 10-30. Characterization of the obtained samples, using X-ray diffraction and Fourier transform infrared spectrophotometry, indicated that the presence of maltodextrins, with the different DE values, does not affect the phase composition and structure of the obtained composites. Morphology studies of the samples, using field emission scanning electron microscope and transmission electron microscope, revealed that maltodextrin has obvious effect on the size, shape, and morphology of hydroxyapatite nanoparticles. In particular, in studied DE range, maltodextrin DE 28-30 with dominant structure of debranched chain is the most preferable choice to obtain the composite with highly dispersed nanoparticles. In vitro assay on pre-osteoblast MC3T3-E1 cells demonstrated the ability of the composites to stimulate alkaline phosphatase activity and mineralization during differentiation of the cells.

Progress in Hydroxyapatite–Starch Based Sustainable Biomaterials for Biomedical Bone Substitution Applications

“…In all the investigation cases, starch has been used due to its polar nature that enhances the adhesion with hydroxyapatite and leads to a composite material. The ion generating solutions usually contain CaCl 2 ,− or Ca­(NO 3 ) 2 , , and Na 2 HPO 4 ,− or (NH 4 ) 2 HPO 4 , respectively. A precipitate is obtained after processing of these solutions.…”

The Effects of Rod and Round-Like Nanohydroxyapatites on Allium cepa Root Meristem Cells

“…Hydroxyapatite (HA) is accepted as the most suitable material in terms of biocompatibility in orthopaedic and dental applications [1]. Over the last decade, nano-hydroxyapatite (nHA) has been used to repair damaged calcified tissues such as bones and teeth, to compose scaffolding, and to deliver drugs [2]. In the nanotechnology industry, which has developed rapidly in recent years, new materials are being developed and delivered to consumers every day in medicine, textiles, cosmetics, and many other areas.…”

The calcination temperature effect in the synthesis of nanohydroxyapatite: characterization and its application as a nanocarrier

“…Because of the chemical composition of calcium phosphate and the shape similar to regular bone, hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) was researched as a biocompatible material (Phan et al 2017;Mansour et al 2016). HA can be used effectively in ODS due to its high specific surface, regular porous structure, high porosity and surface functional groups (Vadia and Rajput 2011).…”