2019
DOI: 10.22270/jddt.v9i4-s.3400
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Synthesis and Characterization of Nanodiamond-Doxorubicin (Dox) Conjugate for Effective Delivery against MCF-7 Cell Lines

Abstract: In this work, we have introduced a carbon nanomaterial (nanodiamond), to bind with anticancer drug doxorubicin (DOX) with via amide bond conjugation for cancer drug delivery and therapy. Nanodiamond (ND) was initially carboxylated by the surface modification along the treatment with strong alkaline solution (H2SO4:HNO3) and then activated the carboxyl moiety of ND with the addition of EDC. Anticancer drugs were bound to the ND through a succession of chemical modifications by adipic acid dihydrazide (ADH). The… Show more

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Cited by 3 publications
(11 citation statements)
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“…Therefore, the development of alternative polymers to replace PEG is needed [40]. In other cases, it is necessary to have polymers that capture, solubilize and control the release of the drug without resorting to chemical conjugation [36], such as Pluronic® micelles [34,41,42], poly(lactic acid) (PLG ), poly(lactic co-glycolic acid) (PLGA) [43], chitin [44,45], chitosan [34,35,42]. For example, a multifunctional co-delivery system that coencapsulates hydrophobic chemotherapeutic drugs (curcumin) and hydrophilic therapeutic drugs (Survivin shRNA genes) in polymer nanoparticles (PLGA polymer and conjugated triblock polymer) is a promising strategy for clinical application in cancer therapy [46].…”
Section: Polymer Therapymentioning
confidence: 99%
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“…Therefore, the development of alternative polymers to replace PEG is needed [40]. In other cases, it is necessary to have polymers that capture, solubilize and control the release of the drug without resorting to chemical conjugation [36], such as Pluronic® micelles [34,41,42], poly(lactic acid) (PLG ), poly(lactic co-glycolic acid) (PLGA) [43], chitin [44,45], chitosan [34,35,42]. For example, a multifunctional co-delivery system that coencapsulates hydrophobic chemotherapeutic drugs (curcumin) and hydrophilic therapeutic drugs (Survivin shRNA genes) in polymer nanoparticles (PLGA polymer and conjugated triblock polymer) is a promising strategy for clinical application in cancer therapy [46].…”
Section: Polymer Therapymentioning
confidence: 99%
“…Biodegradable polymers with a high molecular weight include: polypeptides, dextrins, polysialic acid, polyacetals [36], PLG, PLGA [43], chitosan [34,35], PEG micelles [47], alginate [48], albumin [49][50][51][52][53], pluronic micelles (Pluronic®) [34,41,42,49]. Recently, polyglutamic acid (PGA), which has a high potential among synthetic polypeptides, has been used in nanomedicine [36].…”
Section: Polymer Therapymentioning
confidence: 99%
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