Synthesis and characterization of nanoscale zeolitic imidazolate frameworks with ciprofloxacin and their applications as antimicrobial agents

Nabipour, Hafezeh; Sadr, Moayad Hossaini; Bardajee, Ghasem Rezanejade

doi:10.1039/c7nj00606c

Cited by 108 publications

(42 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Albeit related core-shell metal NP/ZIF-8 composites have been previously reported using other surfactants, 58 or different nanoparticle cores, 59 the inherent aqueous instability of ZIF-8 is well known; indeed, this ZIF-8 characteristic has been used for the progressive release of encapsulated drugs inside cells. 48 , 60 , 61 , 62 Notice that, when such composites are internalized into cells, they tend to accumulate in lysosomes, where the acidic pH accelerates the ZIF-8 degradation and hence the release of the drug. Such aqueous instability is, however, incompatible with the potential use of these nanostructures as biocompatible heterogeneous catalysts.…”

Section: Resultsmentioning

confidence: 99%

Core-Shell Palladium/MOF Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models

Martínez

Carrillo‐Carrión

Destito

et al. 2020

Cell Reports Physical Science

View full text Add to dashboard Cite

Summary Translating the potential of transition metal catalysis to biological and living environments promises to have a profound impact in chemical biology and biomedicine. A major challenge in the field is the creation of metal-based catalysts that remain active over time. Here, we demonstrate that embedding a reactive metallic core within a microporous metal-organic framework-based cloak preserves the catalytic site from passivation and deactivation, while allowing a suitable diffusion of the reactants. Specifically, we report the fabrication of nanoreactors composed of a palladium nanocube core and a nanometric imidazolate framework, which behave as robust, long-lasting nanoreactors capable of removing propargylic groups from phenol-derived pro-fluorophores in biological milieu and inside living cells. These heterogeneous catalysts can be reused within the same cells, promoting the chemical transformation of recurrent batches of reactants. We also report the assembly of tissue-like 3D spheroids containing the nanoreactors and demonstrate that they can perform the reactions in a repeated manner.

show abstract

Section: Resultsmentioning

confidence: 99%

Core-Shell Palladium/MOF Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models

Martínez

Carrillo‐Carrión

Destito

et al. 2020

Cell Reports Physical Science

View full text Add to dashboard Cite

show abstract

“…As arepresentative example,the biocompatible microporous zeolitic imidazolate framework 8( ZIF-8) [3] has been widely proposed for as ustained delivery of aw ide variety of challenging drugs. [4][5][6][7] Although with ap rogressive release, most previous reports refer to that 80-90 %o ft he encapsulated cargo is released within the first % 10 hafter exposure to physiological environments.T hese properties are derived from the chemical instability of ZIF-8 in water, [8] which degrades depending on the ZIF-8 mass-to-water ratio and medium pH, [5,9] thus releasing its cargo.…”

mentioning

confidence: 99%

Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells

et al. 2019

View full text Add to dashboard Cite

Ap lasmonic core-shell gold nanostar/zeoliticimidazolate-framework-8 (ZIF-8) nanocomposite was developed for the thermoplasmonic-driven release of encapsulated active molecules inside living cells.T he nanocomposites were loaded, as aproof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF-8 degradation and bisbenzimide leaking in aqueous media or inside living cells.T he demonstrated molecule-release mechanism relies on the use of near-IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus,b isbenzimide thermodiffusion. Confocal microscopya nd surfaceenhanced Raman spectroscopy( SERS) were used to demonstrate bisbenzimide loading/leaking and near-IR-triggered cargo release inside cells,t herebyleading to DNAs taining.

show abstract

“…Niflumic acid does not exist in the pores. 24 Such a structure will reduce the leakage of niflumic acid. In the pore size distribution diagram in Figure 2, the pores of ZIF-8 and ZIF-NIF are mainly microporous structures, and the pores mostly exist in 0-10 nm.…”

Section: Resultsmentioning

confidence: 99%

“…As a bactericidal factor, Zn(II) can damage cell membranes and cause cell death. 23 Zn(II) as a bactericidal factor, [24][25][26][27] when contacted with the cell membrane of bacteria, because the cell membrane is negatively charged, the two are coulomb attracted, thereby firmly binding, allowing metal ions to penetrate the cell membrane, reacting with proteins after entering the bacteria, destroying the synthesis of enzymes, thereby disturbing The synthesis of its DNA leads to bacterial death. In the previous work, the structure of ZIF-niflumic acid (NIF)-alginate (ALG) was reported, the membrane showed high drug loading, responsive drug release, excellent antibacterial properties, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Mechanism of Zn(II) Frame Supported on Alginate Membrane

Luo

Wang

et al. 2020

Bulletin Korean Chem Soc

View full text Add to dashboard Cite

In order to solve the problem of antibiotic-resistant bacteria caused by excessive use of antibiotics, herein, an antibacterial membrane composed of natural sodium alginate (ALG), zeolite imidazolate skeleton (ZIF-8) and niflumic acid (NIF) was reported. The membrane serves as a versatile platform for local antibacterial. This report carried out in-depth research on the physical properties and antibacterial mechanism of the synthesized sodium alginate composite film. The data shows that the sodium alginate-based antibacterial film has a continuous antibacterial effect, and the release of antibacterial molecules can be controlled according to changes in the external environment. The results show that the complex has stronger mechanical and bacteriostatic properties. Niflumic acid and Zn(II) have synergistic antibacterial effect. The complex promotes bacterial death by hindering bacterial respiratory metabolism and destroying cell membrane structure.

show abstract

Synthesis and characterization of nanoscale zeolitic imidazolate frameworks with ciprofloxacin and their applications as antimicrobial agents

Abstract: The present study investigated antibiotic drug loading in metal–organic frameworks (MOFs).

Cited by 108 publications

References 63 publications

Core-Shell Palladium/MOF Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models

Core-Shell Palladium/MOF Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models

Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells

The Antibacterial Mechanism of Zn(II) Frame Supported on Alginate Membrane

Contact Info

Product

Resources

About