Synthesis and Characterization of NanoscaleHydroxyapatite-Copper for Antimicrobial Activity Towards Bone Tissue Engineering Applications

Sahithi, Kolli; Swetha, M.; Prabaharan, M.; Moorthi, A.; Saranya, N.; Ramasamy, Kumarasamy; Srinivasan, Narasimhan; Partridge, Nicola C.; Selvamurugan, N.

doi:10.1166/jbn.2010.1138

Cited by 67 publications

(35 citation statements)

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“…Silver, in its oxidized form [Ag + ], is an antibacterial agent and it is used in different forms like ionic, metallic, colloidal, etc. [13][14][15][16]. The antibacterial property of metals such as titanium, cobalt, nickel, copper, zinc, zirconium, molybdenum, tin, and lead varies significantly and the effectiveness of metals to resist bacterial attachment varies with the bacterial strain [17].…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering

Sekaran

Nethala

Pattnaik

et al. 2011

International Journal of Biological Macromolecules

277

112

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering

Sekaran

Nethala

Pattnaik

et al. 2011

International Journal of Biological Macromolecules

277

112

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“…Their anti-bacterial activity was found to be enhanced against Gram-positive and Gram-negative bacteria. This material was safe against primary osteoprogenitor cells of rat and documented their usefulness in bone transplant (Sahithi et al 2010). A nanofibrous scaffold of polylactide acid (PLA), hydroxyapatite NPs and super-paramagnetic γ-Fe 2 O 3 NPs have been synthesized.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Singla

Guliani

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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The metallic nanoparticles (NPs) and their synthetic biology are an active area fascinating both the academics as well as scientific research applications in the field of nanotechnology. These nanostructures are a versatile class of materials such as metal NPs, metal oxide NPs, magnetic NPs and quantum dots for biomedical sciences and engineering due to their huge potential. A handful number of methods are adopted for the synthesis of one or the other kind of metal NPs which includes physical and chemical approaches. Each of the chemical and physical synthesis procedures deals with some limitations such as cost ineffectiveness, use of hazardous chemicals, formation of toxic end products and involvement of high-energy processes. To overcome these drawbacks, an alternative approach of environmentally benign and inexpensive biological synthesis mediated by plants or microbes has been essentially adopted. The variations in size, shape and surface chemistry of NPs affect the properties of metal NPs to a greater extent which in turn have an influence on their biological behaviour. Few metal NPs offer unique optical properties while others possess paramagnetic behaviour and quantum size effect which make them suitable in bio-imaging diagnostic techniques. Some metallic NPs play a role in tissue engineering and other therapeutic applications due to their ease of surface modifications, large surface area to volume ratio, unique electrical and anti-microbial activities. Instead of multi-disciplinary applications of metallic NPs, there is a great concern regarding the toxicity issues associated with the use of these NPs which need to be sorted out by looking out certain ways for favourable architecture involving the synthesis methods and parameters for designing the non-toxic NPs for improving the quality of life.

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“…This assay is commonly used to determine the cytotoxicity of potential medical agents and biomaterials since released molecules can cause metabolic dysfunction that decreases or abolishes MTT reduction in the mitochondria and result in cell toxicity (Mosmann, 1983, Denizot andLang, 1986). Thus, MTT reduction is proportional to cellular metabolic activity, and decreased MTT reduction infers a possible toxicity of the biomaterial or drug tested (Chen et al, 2011, Niu et al, 2011, Sahithi et al, 2010, Bispo et al, 2010.…”

Section: Mtt Assaymentioning

confidence: 99%

Oral Bacterial Adhesion and Biocompatibility of Silver-Amorphous Carbon Films: A Surface Modification for Dental Implants

Almaguer-Flore¹,

Rodil²,

Olivares-Navarrete³

2011

Implant Dentistry - The Most Promising Discipline of Dentistry

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Synthesis and Characterization of NanoscaleHydroxyapatite-Copper for Antimicrobial Activity Towards Bone Tissue Engineering Applications

Cited by 67 publications

References 0 publications

Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering

Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Oral Bacterial Adhesion and Biocompatibility of Silver-Amorphous Carbon Films: A Surface Modification for Dental Implants

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