Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

Phuong, Ha Tran; Hương, Trần Thu; Vinh, Le Thi; Khuyen, Hoang Thi; Thao, Do Thi; Hương, Nguyễn Thanh; Lien, Pham Thi; Minh, Le Quoc

doi:10.1016/j.jre.2019.01.005

Cited by 13 publications

(8 citation statements)

References 19 publications

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“…These characteristics are also very useful potential objects for application in highly functional devices. Some rare earth containing luminescent nanorods could be synthesized by wet chemical routes [19][20][21] including our successful work with TbPO 4 nanorods [22]. These results and some other previous studies have shown that the morphology of materials can have important impacts on luminescent intensity.…”

Section: Introductionmentioning

confidence: 57%

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Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Vinh

Hương

Phuong

et al. 2021

Journal of Nanomaterials

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We report on the synthesis and characterization of folic acid-conjugated silica-modified TbPO4·H2O nanorods for biomedical applications. The uniform shape TbPO4·H2O nanorods with a hexagonal phase were successfully synthesized by wet chemical methods. A novel TbPO4·H2O@silica-NH2 nanocomplex was then formed by functionalizing these nanorods with silica and conjugating with biological agents. The field emission scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction reveal the morphology and structure of the nanorods, with their controllable sizes (500-800 nm in length and 50-80 nm in diameter). The Fourier transform infrared spectroscopy was employed to identify chemical substances or functional groups of the TbPO4·H2O@silica-NH2 nanocomplex. The photoluminescence spectra show the four emission lines of TbPO4·H2O@silica-NH2 in folic acid at 488, 540, 585, and 621 nm under 355 nm laser excitation, which could be attributed to the 5D4-7 F j ( J = 6 , 5 , 4 , 3 ) transitions of Tb3+. The TbPO4·H2O@silica-NH2 nanorods were conjugated with folic acid for the detection of MCF7 breast cancer cells. The obtained results show a promising possibility for the recognition of living cells that is of crucial importance in biolabeling.

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Section: Introductionmentioning

confidence: 57%

“…After TbPO 4 •H 2 O nanorods were protected with silica and then functionalized with amine and folic acid groups, there are three absorption peaks at 2091 cm -1 , 1643 cm -1 , and 1438 cm -1 corresponding to the vibrations of the N-H, C=O group [20,23].…”

Section: The Fouriermentioning

confidence: 99%

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Vinh

Hương

Phuong

et al. 2021

Journal of Nanomaterials

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“…The cells were seeded at a density of 5.10 4 cells/mL. 29 To study the uptake capacity of functionalized NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS, the MCF-7 breast cancer cells and HEK-293A cells (10 6 cells/mL) at log phase were seeded in 24-well plates and then incubated for 24 h. Poly(ethylene glycol) 1500 (Sigma) and NaYF 4 :Yb 3+ / Er 3+ @silica/NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS nanoparticles (with a concentration of 20 μg/mL) were then added to the cell-seeded wells for 3 h. After the assigned time, the culture medium was discarded, and cells were harvested into 15 mL falcon tubes. The cell tubes were centrifuged at 1000 rpm for 5 min to thoroughly remove the culture medium.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Upconversion NaYF₄:Yb³⁺/Er³⁺@silica-TPGS Bio-Nano Complexes: Synthesis, Characterization, and In Vitro Tests for Labeling Cancer Cells

et al. 2021

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Fluorescence imaging is an important technique used for early diagnosis and effective treatment of some incurable diseases including cancer. Herein, we report novel NaYF 4 :Yb 3+ / Er 3+ @silica-TPGS bio-nano complexes for labeling cancer cells. The NaYF 4 :Yb 3+ /Er 3+ nanoparticles have been successfully synthesized via a hydrothermal route, further coated with a silica shell, and functionalized with D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). The experimental results indicate that NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS emits stronger upconversion luminescence than NaYF 4 :Yb 3+ /Er 3+ under an excitation of 980 nm. More significantly, the NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS bio-nano complexes could strongly label MCF-7 breast cancer cells for in vitro experiments detected by a fluorescence microscope. On the other hand, the complex could not typically probe healthy cells, which are HEK-293A human embryonic kidney cells, under the same experimental conditions. Because of their strong upconversion luminescence, good dispersibility, and biocompatibility, NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS bio-nano complexes can be a promising candidate/probe for biomedical labeling and diagnostics.

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“…In order to overcome the limitations of the above methods. Fluorescent sensors [31][32][33] has entered our sight for its high sensitivity, speci-city and low cost.…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, AA does not continue to react with Fe( ii ). 33 Both Sn( ii ) and AA can react with Fe( iii ), the Fe( ii ) produced can react with 1,10-phenanthroline to form an orange complex, this complex has strong absorption band in the range of 350 nm to 600 nm, the absorption band overlaps the green emission peak of UCNPs at 540 nm. Based on the IFE, Fe( ii )–1,10-phenanthroline as fluorescent absorber.…”

Section: Introductionmentioning

confidence: 99%

Inner filter effect between upconversion nanoparticles and Fe(ii)–1,10-phenanthroline complex for the detection of Sn(ii) and ascorbic acid (AA)

Song

Zhou

et al. 2021

RSC Adv.

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Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

Cited by 13 publications

References 19 publications

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Upconversion NaYF₄:Yb³⁺/Er³⁺@silica-TPGS Bio-Nano Complexes: Synthesis, Characterization, and In Vitro Tests for Labeling Cancer Cells

Inner filter effect between upconversion nanoparticles and Fe(ii)–1,10-phenanthroline complex for the detection of Sn(ii) and ascorbic acid (AA)

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Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

Cited by 13 publications

References 19 publications

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Upconversion NaYF4:Yb3+/Er3+@silica-TPGS Bio-Nano Complexes: Synthesis, Characterization, and In Vitro Tests for Labeling Cancer Cells

Inner filter effect between upconversion nanoparticles and Fe(ii)–1,10-phenanthroline complex for the detection of Sn(ii) and ascorbic acid (AA)

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Upconversion NaYF₄:Yb³⁺/Er³⁺@silica-TPGS Bio-Nano Complexes: Synthesis, Characterization, and In Vitro Tests for Labeling Cancer Cells