Synthesis and Characterization of New 1‐(4‐Methylpiperazin‐1‐yl)thioureas as Potential Antitubercular Agents

Abstract

Synthesis, characterization, and preliminary biological assessments of compounds with antitubercular activity.

The Synthesis and Antimicrobial Properties of New 2-(R-Phenylimino)-1,3-thiazoline Derivatives Containing the N-Methylpiperazine Moiety

“…The synthesis of all asymmetric thioureas with the fragment of N-methylpiperazine is based on the classical reaction of the interaction N-methyl-N 1 -aminopiperazine with the corresponding aromatic isothiocyanates [9,10]. We have shown that asymmetric thioureas 5a-e can be obtained by the condensation of N-methyl-N 1aminopiperazine 4 with the corresponding N 1 -aryl-N,Ndimethylthioureas 3a-e.…”

“…The antibacterial [3], antifungal [4,5], anti-inflammatory, analgesic and kinase CDK1 inhibition [6,7] activities are reported for iminothiazole-containing heterocyles. N-methylpiperazine derivatives containing the azole nucleus possess the antifungal [8], antituberculosic [9,10] and antimicrobial [9] activities.…”

“…The nucleus of iminothiazole-containing heterocyles -2-iminothiazole -is generally prepared by the single-stage reaction of thiourea and α-halocarbonyls where thiourea should be disubstituted at both nitrogen atoms [9][10][11][12][13]. Unsymmetric thioureas can be synthesized from amines.…”

A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity

“…In a similar vein, compound (94m) had a diameter of inhibition higher than 10 mm at 200 μg. (Scheme 19) [34] Amaroju Suresh et al designed, synthesized, and tested new substituted sulfonamide tetrazole derivatives as antitubercular agents. As shown in Scheme 20, the proposed compounds were synthesized in seven steps.…”

“…In a similar vein, compound (94m) had a diameter of inhibition higher than 10 mm at 200 μg. (Scheme 19) [34] …”