Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Abstract

A new pH-responsive carrier matrix was designed from combination of shellac (Sh), hydroxpropylmethylcellulose (HPMC) and acrylic acid (AA). Characterization of materials was done using various advanced instrumentation techniques. The kinetics of thermal decomposition of materials were studied and compared using Coats-Redfern (CR) and Kissinger-Akahira-Sunose (KAS) mathematical models. The Arrhenius equations for thermal decomposition of shellac and chemically modified shellac (Sh-HPMC-AA) were computed to be k = (3.4 9 10 21 ) e -159.9/RT and k = (141.8) e -19.6/RT s -1 , respectively. The pHresponsive characteristics of Sh-HPMC-AA shows 288% swelling ratio. Further, the controlled release of 5-amino salicylic acid (5-ASA) was studied in buffer medium and Fick's diffusion equation was applied for calculation of transport phenomenon. The enzymatic degradation study of Sh-HPMC-AA is also reported.

Blends of synthetic plastic-derived polypeptide with Hydroxypropylmethylcellulose and polyvinyl alcohol: unraveling the specific interaction parameters, morphology and thermal stability of the polymers couple

“…HPMC films are strong, resilient, entirely lucid, odor-free, tasteless, and oleophobic. HPMC finds importance in pharmaceuticals, controlled drug delivery, materials for biomedical field [7,8]. PVA is the member of famous polymers of mammoth significance by reason of ease of preparation, distinct, enviable distinctiveness prominently for pharmaceutical and biomedical applications.…”

Manipulation of the Glass Transition Properties of a High-Solid System Made of Acrylic Acid-N,N′-Methylenebisacrylamide Copolymer Grafted on Hydroxypropyl Methyl Cellulose

“…The smooth-surface appearance of the matrix in Figure 3 indicates good miscibility for AAc with HPMC and the formation of a new co-polymer argued by the infrared spectroscopy results in Figure 1 . The new morphological features of the HMPC-AAc network should be supported by the outcome of a combination of electrostatic forces, resulting from the presence of contiguous functional groups such as carboxylates, and hydrogen bonding that occurs between adjacent chain segments [ 36 , 37 ]. Microscopy images are consistent with the discussion of X-ray diffractograms ( Figure 2 ) on the highly amorphous nature of this co-polymer, hence inviting application of the glass-transition theory on the mechanical measurements of the following section.…”

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

“…Drug release from shellac-based matrix tablets is influenced by various factors, such as reaction conditions, ,,− additive − and drug patterns, , and matrix forms, as shown in Table . Shellac-based tablets with controlled drug release behaviors can be prepared by annealing. , Increasing the annealing temperature and shellac content improves the hardness and disintegration time of shellac-based tablets and converts the drug release kinetics from relaxation-controlled to diffusion-controlled release through the in situ polymerization of shellac during annealing. , Similar to the increase in hardness caused by annealing, matrix tablets annealed at 100 °C showed significantly less erosion after a dissolution test (Figure A), which might contribute to a slower drug release .…”

“…Another study reported a pH-responsive carrier matrix designed by chemical cross-linking shellac, hydroxypropyl methylcellulose (HPMC), and acrylic acid (AA) (shellac-HPMC-AA). It controlled the release of 5-amino salicylic acid by Fickian diffusion …”

“…It controlled the release of 5-amino salicylic acid by Fickian diffusion. 87 In contrast to most matrices, shellac has enteric solubility and can be modified according to actual need, which widens the potential applications of shellac-based tablets. Meanwhile, benefiting from the amphiphilicity of shellac, its application as a matrix for embedding and delivering essential oils is one of its most promising applications, as this function is difficult to realize in conventional tablets.…”