Synthesis and Characterization of New 2-(2-Thienyl)-5- Aryl-1,3,4-Oxadiazoles

Abstract

A series of new 1,3,4-oxadiazole derivatives incorporating thiophene moiety were synthesized by the cyclization of N-(2thenoyl)-N'-aroylhydrazine in the presence of phosphorus oxychloride. The intermediate and final compounds were characterized by infrared (IR), nuclear magnetic resonance ( 1 H-NMR and 13 C-NMR) spectroscopy, and by their physicochemical properties. RezumatAu fost sintetizați o serie de noi derivați ai 1,3,4-oxadiazolului având și un nucleu tiofenic, prin ciclizarea N-(2-tenoil)-N'aroilhidrazinei în prezența oxiclorurii de fosfor. Compușii intermediari și cei finali au fost caracterizați prin spectroscopie în infraroșu (IR) și rezonanță magnetică nucleară ( 1 H-RMN și 13 C-RMN), precum și prin proprietățile lor fizico-chimice.

A One-Pot Assembly of Fully Substituted Alkyl 5-Aminothiophene-2-carboxylates from Allenes, Isothiocyanates, and Alkyl 2-Bromoacetates

“…They have a broad spectrum of biological activity, are part of many pharmaceuticals including drugs for treatment of socially significant diseases (HIV, tuberculosis, cancer, flu, etc. ), , a variety of electronic and optoelectronic materials and conductive polymers or serve as important intermediates and building blocks for the synthesis of the above products . Given the synthetic and practical significance of thiophenes and their derivatives, the search for and development of conceptually new rational methodologies for their synthesis, as well as a fundamental extension of their range has acquired particular importance .…”

Synthesis, Structural Determination, Docking Study and Bioactivity of Novel Thiophene Derivatives

“…In particular, their antimicrobial activity has become a focal point in light of the global threat of antimicrobial resistance [4][5][6]. The antimicrobial properties of thiophene can be attributed to the crucial role-played by the sulfur atom within the thiophene ring [7]. This sulfur atom possesses distinct characteristics that contribute to the antimicrobial efficacy of thiophene derivatives [8].…”