Synthesis and characterization of new highly fluorinated phosphoramidates bearing different alkylamino groups

Abstract

General procedure for the synthesis of fluorinated phosphoramidates from dichlorophosphoramidates Cl2P(O)NHR (Method A):The dichlorophosphoramidate (1 equiv., 4.46 mmol) was dissolved in 10 mL of anhydrous diethyl ether and cooled to 0°C, followed by addition of a solution of fluorinated alcohol (2 equiv., 8.93 mmol), triethylamine (2 equiv., 8.93 mmol), and 15% DMAP in 15 mL of anhydrous diethyl ether.After addition, the temperature was raised to room temperature and then refluxed for 48 hours. Bis(2,2,2-trifluoroethyl) propylphosphoramidate (7)