Synthesis and characterization of new 1,4-dihydropyran derivatives by novel Ta-MOF nanostructures as reusable nanocatalyst with antimicrobial activity

Ahmad, Irfan; Jasim, Saade Abdalkareem; Al-Qargholi, Basim; Hammid, Ali Thaeer

doi:10.3389/fchem.2022.967111

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…To 25 mL of double-distilled water, 1 mmol copper (II) chloride and 2 mmol of pyridine-2,6-dicarboxylic acid were added and stirred for 15 min at 50 C to create a homogenized mixture. After cooling to room temperature, microwave radiation was irradiated at room temperature for 15 min with a power of 300 W ( Ahmad et al, 2022 ). With nanofiltration, copper metal–organic frameworks (Cu-MOFs) were separated and washed three times with ethanol and three times with ethanol and double-distilled water.…”

Section: Materials Devices and Methodsmentioning

confidence: 99%

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Abdulkadhim,

Husein Kamona,

Shamikh Al-Saedi

et al. 2024

Front. Chem.

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Recently, nanoscience, especially metal–organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; and copper metal–organic frameworks (Cu-MOFs), a new penicillinoate@copper metal–organic framework (penicillinoate@Cu-MOF) was synthesized. The structure and characterization of the newly synthesized compound were determined using FT-IR spectrums, EDAX analysis, elemental analysis, XRD patterns, SEM images, nitrogen adsorption/desorption curves, and TGA curve. Then, its antimicrobial effects were evaluated on numerous Gram-positive and Gram-negative bacterial strains and were compared with those of penicillin and gentamicin. In continuation of the biological activities, antioxidant tests were performed on the compounds using the DPPH method. For biological activities, the synthesized penicillinoate@Cu-MOF is much more effective than penicillin and Cu-MOF. The loading of penicillin on the nanostructure and the presence of copper in the final composition can be attributed to the high antibiotic properties of the synthesized composition.

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Section: Materials Devices and Methodsmentioning

confidence: 99%

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Abdulkadhim,

Husein Kamona,

Shamikh Al-Saedi

et al. 2024

Front. Chem.

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“…The absorptions observed in the FT-IR spectrum (Figure 4) near 655 cm −1 , 1,150 cm −1 , 1,420 cm −1 , 1710 cm −1 , and 2,900 cm −1 were related to Ti-O (Al-Amin et al, 2016), C-O (Alkhatami et al, 2023), C=C (Alkhatami et al, 2023), C=O (Akhavan-Sigari et al, 2022), and C-H (Ahmad et al, 2022), respectively. The BTB has three carboxylic acid groups, but the broad band due to O-H groups (near 3,200-3,500 cm−1) was not observed in the spectrum of the final product.…”

Section: Synthesis Of Ti/btb-mofmentioning

confidence: 98%

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Altharawi,

Alqahtani,

Aldakhil

et al. 2024

Front. Chem.

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Nano compounds, especially metal-organic frameworks (MOFs), have significant properties. Among the most important properties of these compounds, which depend on their specific surface area and porosity, are biological properties, such as anticancer and antibacterial properties. In this study, a new titanium/BTB metal-organic framework (Ti/BTB-MOF) was synthesized by using titanium nitrate and 1,3,5-Tris(4-carboxyphenyl)benzene (BTB) under microwave radiation. The structure of the synthesized Ti/BTB-MOF was characterized and confirmed using X-ray diffraction (XRD) patterns, X-ray photoelectron spectroscopy (XPS) analysis, Fourier transform infrared (FT-IR) spectra, energy-dispersive X-ray (EDAX) analysis mapping, scanning electron microscope (SEM) images, thermogravimetric analysis (TGA) curves, and Brunauer–Emmett–Teller (BET) analysis. The in vitro anticancer properties of Ti/BTB-MOF were evaluated using the MTT method against MG-63/bone cancer cells and A-431/skin cancer cells. The in vitro antibacterial activity was tested using the Clinical and Laboratory Standards Institute (CLSI) guidelines. In the anticancer activity, IC50 (half-maximal inhibitory concentration) values of 152 μg/mL and 201 μg/mL for MG-63/bone cancer cells and A-431/skin cancer cells, respectively, were observed. In the antibacterial activity, minimum inhibitory concentrations (MICs) of 2–64 μg/mL were observed against studied pathogenic strains. The antimicrobial activity of Ti/BTB-MOF was higher than that of penicillin and gentamicin. Therefore, the synthesized Ti/BTB-MOF could be introduced as a suitable bioactive candidate.

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“…The obtained sediments were separated by centrifugation and washed three times with water and ethanol. Finally, the obtained copper-containing MOF nanostructures were dried under vacuum for 48 h at room temperature (Ahmad et al, 2022).…”

Section: Synthesis Of Copper-containing Mof Nanostructuresmentioning

confidence: 99%

“…In a Pyrex tube, 30 mL double-distilled water, 0.835 g dipicolinic acid (5 mmol), and 0.915 g cobalt nitrate (5 mmol) were added. Other steps to the synthesis and purification of cobalt-containing MOF nanostructures were similar to copper-containing MOF nanostructures (Ahmad et al, 2022).…”

Section: Synthesis Of Cobalt-containing Mof Nanostructuresmentioning

confidence: 99%

Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

Asiri,

Jawad BahrAluloom,

Abdullateef Alzubaidi

et al. 2023

Front. Mater.

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Several biological properties of metal–organic frameworks (MOFs) and fiber compounds have been reported, and combinations of these structures can have unique properties. In this study, copper-containing and cobalt-containing MOF nanostructures were synthesized by the ultrasonic technique. Then, novel Cu/Co-hybrid MOF nanostructures were synthesized using the ultrasonic method. Synthesized Cu/Co-hybrid MOF nanostructures were used as a new and efficient recyclable catalyst in the synthesis of pyrano[2,3-c]pyrazole derivatives using the four-component reaction of phenylhydrazine, ethyl acetoacetate, malononitrile, and aldehyde. In the following, novel Cu/Co-hybrid MOF/PVA (poly vinyl alcohol) fiber nanostructures were synthesized by electrospinning and using Cu/Co-hybrid MOF nanostructures and PVA. The structures of the Cu/Co-hybrid MOF nanostructures and the Cu/Co-hybrid MOF/PVA fiber nanostructures were identified and confirmed using BET, TGA, FTIR, SEM, and XRD. In biological studies, the antibacterial, antifungal, and cytotoxicity activities of Cu/Co-hybrid MOF and Cu/Co-hybrid MOF/PVA fiber nanostructures were evaluated. In investigating the catalytic activity of Cu/Co-hybrid MOF, pyrano[2,3-c]pyrazole derivatives were synthesized with higher efficiency and less time than previously reported methods. High antibacterial (against gram-negative and gram-positive strains) and antifungal properties of synthesized Cu/Co-hybrid MOF nanostructures and Cu/Co-hybrid MOF/PVA fiber nanostructures were observed (MIC between 16 and 256 μg/mL), which were higher than some commercial drugs. In the investigation of cytotoxicity activity, the effectiveness on breast cancer cells was studied. The maximum cell proliferation and viability for Cu/Co-hybrid MOF and Cu/Co-hybrid MOF/PVA fiber nanostructures were 38% and 38% higher than the control in a concentration of 200 μg/mL after 48 h. The high catalytic and biological properties of the synthesized nanoparticles can be attributed to the presence of nano-sized bioactive metals and their high specific surface area. The significant physical-chemical properties obtained for synthesized nanoparticles in this study can be related to the desirable synthesis methods, the development of materials with high purity, and the incorporation of hybrid compounds into the nanostructures.

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Synthesis and characterization of new 1,4-dihydropyran derivatives by novel Ta-MOF nanostructures as reusable nanocatalyst with antimicrobial activity

Cited by 10 publications

References 43 publications

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

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