Synthesis and Characterization of Novel Stilbene Derivatives with 1,3,4‐Oxadiazole Unit

Abstract

Four novel stilbene derivatives containing 1,3,4-oxadiazole unit have been synthesized in four steps with overall yields (27~35%). The synthetic route involved one-step installation of 2,5-di-p-tolyl-1,3,4-oxadiazol via the direct coupling of p-toluic acid with hydrazine hydrate promoted by PPA, benzylic bromination, conventional phosphonate formation, and Wittig-Horner olefination.