Synthesis and Characterization of Novel  Aromatic Substituted γ- and δ-Ketoxime Esters

Hasdemir, Belma

doi:10.18596/jotcsa.290589

Cited by 1 publication

(3 citation statements)

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“…The five hydroxyimino compounds ( 2a–e ) were synthesized and characterized in a previous study by our group . The other ten substances ( 3a–e ; 4a–e ) were synthesized in this work for the first time.…”

Section: Resultsmentioning

confidence: 99%

“…The solvent was evaporated and the crude product was subjected to column chromatography on silica gel and as eluent ( n ‐hexane/ethyl acetate 7:3) to yield the oximes 2a–e . The products 2a–e were synthesized and characterized according to literature …”

Section: Methodsmentioning

confidence: 99%

“…1a–e were converted to their original series of aryl, substituted aryl and heteroaryl γ‐methoxy‐ ( 3a–e ) and γ‐benzyloxyimino‐ ( 4a–e ) butyric acid methyl esters. 2a–e were synthesized before by our group . 2b , 2c , 2d were original compounds.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and elastase inhibition activities of novel aryl, substituted aryl, and heteroaryl oxime ester derivatives

Hasdemir

Saçan

Yaşa

et al. 2017

Archiv der Pharmazie

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Fifteen novel aryl, substituted aryl and heteroaryl γ-hydroxy- (2a-e), γ-methoxyimino- (3a-e), and γ-benzyloxyimino- (4a-e) butyric acid methyl esters were investigated for their enzyme inhibition, and the synthesis of 10 compounds (3a-e, 4a-e) is given in this study. The other five compounds (2a-e) were synthesized before in another study. Compounds 3a-e and 4a-e were synthesized in this work as original compounds and characterized by H and C NMR, IR, mass, and elemental analyses. Their (E/Z)-isomerisation ratios were analyzed by H and C NMR. All of them are of pure (E)-configuration. Due to the literature survey, the elastase inhibition activity was not studied for these compounds. Elastase inhibition ability was investigated in this work for five γ-hydroxy- (2a-e), five γ-methoxy- (3a-e), and five γ-benzyloxyimino- (4a-e) butyric acid methyl esters. All these 15 compounds showed elastase inhibition activity. Compound 2b was the best one and exhibited a better activity than the standard ursolic acid whereas compound 2a worked like the standard. All these compounds can be novel elastase inhibitor agents in the pharmaceutical and cosmetic industries.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%