Synthesis and characterization of novel dual environment-responsive hydrogels of Hydroxyethyl methacrylate and Methyl cellulose

Abstract

The current study describes the synthesis and characterization of dual environment-responsive semi-interpenetrating hydrogels of polyhydroxyethyl methacrylate (pHEMA) and methyl cellulose (MC). HEMA was polymerized using free radical polymerization technique. Different proportions of MC were incorporated within the pHEMA matrix to induce environment-sensitive property. The microstructures of the hydrogels were studied under bright field microscopy. The hydrogels were thoroughly characterized using XRD, FTIR, swelling, mechanical and electrical studies. The micrographs of the hydrogels suggested formation of biphasic system. At lower proportions of MC, the hydrogels were oil-in-water type of formulations. An increase in the MC content resulted in the formation of bicontinuous biphasic formulations. Mechanical analysis suggested viscoelastic solid nature of the hydrogels. An increase in the MC content resulted in the increase in the viscous component. The electrical studies suggested resistive dominant behavior of the hydrogels. Thermal studies suggested better moisture retention capacity of the MC containing hydrogels. The hydrogels were found to be biocompatible in nature.

Polysaccharides in Ocular Drug Delivery

“…The semi-interpenetrating hydrogels of polyhydroxyethyl methacrylate and methylcellulose are also thermosensitive. An increase in the methylcellulose content increases the viscous component and provides a better moisture retention capacity of the methylcellulose-containing hydrogels, making them suitable for ophthalmic applications [89].…”

Improvement of tribological properties of water‐based ZnO nanoparticles lubricant for zirconium alloy cold rolling by hydroxyethyl cellulose

“…This is due to the high water retention capacity of HEC. 30 In water-based lubricants, hydroxyl and water molecules form a hydrated molecular layer, which increases the viscosity of the lubricant, 31 and the hydrated molecular layer attaches to the friction surface to form a lubricating layer, which improves the tribological properties.…”

Synthesis and characterization of controlled drug release carriers based on functionalized amphiphilic block copolymers and super‐paramagnetic iron oxide nanoparticles

“…[1][2][3][4] The importance of targeted drug delivery is to transport a drug directly to the center of the disease under various external stimuli such as temperature, pH, magnetic field, and light, thereby treating the disease deliberately with no effects on the body. [5,6] Therefore, preparing micelles merely depending on the self-assembly of block copolymers in aqueous solution and benefit from the absence of any organic solvents and surfactants can lead to lower toxicity and eliminating potential harm. Magnetic nanoparticles (MNPs) are being of great interest in medicinal applications because of their biocompatibility and super-paramagnetic nature.…”

“…In recent years, self‐assembled polymeric micelles from biodegradable and biocompatible amphiphilic block copolymers such as poly(lactic acid)–poly(ethylene glycol) (PLA–PEG), poly(ε‐caprolactone)–poly(ethylene glycol) (PCL–PEG), PCL–PLA–PEG, and PEG–[ b ‐PCL– b ‐poly(acrylic acid) (PAA)] 2 have been examined in drug delivery systems because of their unique characteristics . The importance of targeted drug delivery is to transport a drug directly to the center of the disease under various external stimuli such as temperature, pH, magnetic field, and light, thereby treating the disease deliberately with no effects on the body . Therefore, preparing micelles merely depending on the self‐assembly of block copolymers in aqueous solution and benefit from the absence of any organic solvents and surfactants can lead to lower toxicity and eliminating potential harm.…”