Synthesis and characterization of novel polymer-hybrid silver nanoparticles and its biomedical study

Verma, Suresh K.; Jha, Ealisha; Kiran, Kumari; Bhat, Suresh; Suar, Mrutyunjay; Mohanty, Priti S.

doi:10.1016/j.matpr.2016.04.096

Cited by 21 publications

(12 citation statements)

References 21 publications

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“…The UV-Vis spectrum analysis exhibited a sharp peak. The exhibition of absorbance peak was reported as being distinguished properties of nanoparticles to classify their optical properties [26]. Green synthesized CaONP showed peak absorbance at 287 nm.…”

Section: Green Synthesis and Characterization Of Caonpmentioning

confidence: 99%

Cellular Investigations on Mechanistic Biocompatibility of Green Synthesized Calcium Oxide Nanoparticles with Danio rerio

Eram

Kumari

Panda

et al. 2021

JNT

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The utility of calcium oxide nanoparticles in the biomedical and physical fields has instigated their biocompatible synthesis and production. Moreover, it is important to investigate their biocompatibility at the molecular level for biomedical and ecotoxicological concern. This study explores the green synthesis of calcium oxide nanoparticles (CaONP) using Crescentia cujete leaf extract. The synthesized CaONP were found to have a size of 62 ± 06 nm and a hydrodynamic diameter of 246 ± 12 nm, as determined by FE-SEM and dynamic light scattering (DLS). CaONP was stable in fish medium with a zeta potential of −23 ± 11 mV. The biocompatibility of the CaONP was investigated with adult zebrafish bearing an LC50 of 86.32 µg/mL. Cellular and molecular investigation revealed the mechanism of biocompatibility as a consequence of elicited reactive oxygen species leading to apoptosis, due to accumulation and internalization of CaONP in exposed zebrafish. The study provided detailed information about the mechanistic biocompatibility and a defined horizon of green synthesis of CaONP for biomedical and ecological purposes.

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Section: Green Synthesis and Characterization Of Caonpmentioning

confidence: 99%

Cellular Investigations on Mechanistic Biocompatibility of Green Synthesized Calcium Oxide Nanoparticles with Danio rerio

Eram

Kumari

Panda

et al. 2021

JNT

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“…In the recent few decades, nanotechnology’s implications have progressed to a higher level. Various forms of organic and inorganic nanoparticles, particularly metal nanoparticles and their composites, have been investigated extensively and used in a variety of applications ( Verma et al, 2018a , 2016 ). Metal oxide nanoparticles have shown to have potential and a broad range of applications in the biomedical area, including anticancer drug/gene delivery, cell imaging, and biosensing ( Khalil et al, 2017 ; Mishra et al, 2017 ; Verma et al, 2018b ).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells

Berehu

Anupriya

Khan

et al. 2021

Front. Bioeng. Biotechnol.

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Chemotherapy side effects, medication resistance, and tumor metastasis impede the advancement of cancer treatments, resulting in a poor prognosis for cancer patients. In the last decade, nanoparticles (NPs) have emerged as a promising drug delivery system. Swertia chirayita has long been used as a treatment option to treat a variety of ailments. Zinc oxide nanoparticles (ZnO-NPs) were synthesized from ethanolic and methanolic extract of S. chirayita leaves. ZnO-NPs were characterized using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron Microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), and X-ray diffraction (XRD). Its anti-cancer activities were analyzed using cytotoxicity assays [MTT assay and acridine orange (AO) staining] and quantitative real-time PCR (qRT-PCR) using colorectal cancer (CRC) cells (HCT-116 and Caco-2) and control cells (HEK-293). The ZnO-NPs synthesized from the ethanolic extract of S. chirayita have an average size of 24.67 nm, whereas those from methanolic extract have an average size of 22.95 nm with a spherical shape. MTT assay showed NPs’ cytotoxic potential on cancer cells (HCT-116 and Caco-2) when compared to control cells (HEK-293). The IC50 values of ethanolic and methanolic extract ZnO-NPs for HCT-116, Caco-2, and HEK-293 were 34.356 ± 2.71 and 32.856 ± 2.99 μg/ml, 52.15 ± 8.23 and 63.1 ± 12.09 μg/ml, and 582.84 ± 5.26 and 615.35 ± 4.74 μg/ml, respectively. Acridine orange staining confirmed the ability of ZnO-NPs to induce apoptosis. qRT-PCR analysis revealed significantly enhanced expression of E-cadherin whereas a reduced expression of vimentin and CDK-1. Altogether, these results suggested anti-cancer properties of synthesized ZnO-NPs in CRC.

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“…There is a lack of an adhesion barrier easy to use that could be use both in open surgery, laparoscopy and hysteroscopy. Recently, a broad range of polymer have been developed in several medicine domains and represent a technological advance for healthcare [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model

et al. 2018

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BackgroundPeritoneal adhesions are a serious surgical postoperative complication. The aim of this study is to investigate, in a rat model, the anti-adhesive effects of a bioabsorbable film of polymer combining polyethylene glycol and polylactic acid.Materials and methodsSixty-three animals were randomized into five groups according to the anti-adhesion treatment: Hyalobarrier®, Seprafilm®, Polymer A (PA), Polymer B (PB), and control. The rats were euthanized on days 5 and 12 to evaluate the extent, severity and degree of adhesions and histopathological changes. Three animals were euthanized at day 2 in PA, PB and control groups to observe the in vivo elimination.ResultsMacroscopic adhesion formation was significantly lower in the PA group than in the control group at day 5 (median adhesion score 0±0 vs 9.6 ±0.5 p = 0.002) and at day 12 (0±0 vs 7.3±4 p = 0.02). Furthermore, median adhesion score at day 5 was significantly lower in the PA group than in the Seprafilm group (0±0 vs 4.2± 3.9 p = 0.03). Residence time of PA seems longer than PB.ConclusionThe PA bioabsorbable film seems efficient in preventing the formation of peritoneal adhesions.

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Synthesis and characterization of novel polymer-hybrid silver nanoparticles and its biomedical study

Cited by 21 publications

References 21 publications

Cellular Investigations on Mechanistic Biocompatibility of Green Synthesized Calcium Oxide Nanoparticles with Danio rerio

Cellular Investigations on Mechanistic Biocompatibility of Green Synthesized Calcium Oxide Nanoparticles with Danio rerio

Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells

A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model

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