Synthesis and characterization of novel quaternized 2, 3-(diethylmethylamino)phenoxy tetrasubstituted Indium and Gallium phthalocyanines and comparison of their antimicrobial and antioxidant properties with different phthalocyanines

Investigation of tyrosinase enzyme (from mushroom) inhibitory activities and antioxidant properties of new fluorine‐containing phthalocyanines

“…In these studies, the activity of the molecules was interpreted depending on the functional groups and metal atoms in their structures. Among the molecules analyzed in each study, quaternized 2,3‐(diethylmethylamino)phenoxy‐tetra‐substituted Co‐Pc with 58%, [ 41 ] 2(3),9(10),16(17)23(24)‐tetrakis(4‐methoxyphenoxy)cobalt(II) phthalocyanine with 68%, [ 42 ] tetrakis‐[(3,4,5‐trimethoxybenzyloxy)phthalocyaninato]cobalt(II) phthalocyanine with 67.9%, [ 43 ] and 4‐(2‐oxo‐2 H ‐chromen‐3‐yloxy)phthalonitrile Cu(II) with 70.3% [ 44 ] exhibited the highest DPPH radical scavenging activity.…”

Synthesis, Photophysical and Biological Properties of New Phthalocyanines Bearing Peripherally 4‐(Trifluoromethoxy)phenoxy Groups

“…Antioxidant activities of phthalocyanine molecules have been involved in many studies . DPPH radical scavenging activities of Pc molecules ranged from 71.83% to 29.3% at highest studied concentrations.…”

“…Antioxidant activities of phthalocyanine molecules have been involved in many studies . DPPH radical scavenging activities of Pc molecules ranged from 71.83% to 29.3% at highest studied concentrations. In the light of this information, it is possible to say that DPPH scavenging activities of molecules synthesized in our study were moderate with 49.14 ± 0.09% scavenging activity of H 2 Pc molecule at 1500 μg/mL concentration.…”

Turning Photons into Drugs: Phthalocyanine‐Based Photosensitizers as Efficient Photoantimicrobials

“…Finally, dendrimeric 38 only accomplished a modest 2 log CFU mL −1 reduction under the more extreme conditions of 50 μ m and 100 J cm −2 . In another study, Saki et al [63] . examined the antimicrobial activities of five metallo‐ (Cu, Co, Zn, Ga and In) or non‐metallo‐ octasubstituted Pc derivatives bearing diethylaminophenoxy‐ and chloro‐substituents at peripheral positions.…”

“…While 36 and 38 achieved am icrobial reduction of > 6l og 10 (1 mm, 60 Jcm À2 )a gainst S. aureus and 37 achieved ar eduction of 3log CFU mL À1 (1 mm and 60 Jcm À2 ), for E. coli the effect was much lower;a6log CFU mL À1 reduction was achieved at 2.5 mm for 36 and 5 mm for 38 at a3 0Jcm À2 light dose; 37 requiredh arsher photodynamic conditions for a5log reduction (5 mm,6 0Jcm À2 ). Finally,d endrimeric 38 only accomplished a modest 2log CFU mL À1 reduction under the more extreme conditions of 50 mm and 100 Jcm À2 .I na nother study,S aki et al [63] examined the antimicrobiala ctivities of five metallo-(Cu, Co, Zn, Ga and In) or non-metallo-octasubstituted Pc derivatives bearing diethylaminophenoxy-andc hloro-substituents at peripheralp ositions. Disc diffusion and microdilution assayss howed that among all the tested Pcs, only positively charged quaternized phthalocyanine molecules containing Ga and In metal centres showed antimicrobiala ctivity against E. coli and B. subtilis.…”