Synthesis and characterization of novel halloysite-incorporated adhesive resins

Feitosa, Sabrina; Münchow, Eliseu A.; Al-Zain, Afnan O.; Kamocki, Krzysztof; Platt, Jeffrey A.; Bottino, Marco C.

doi:10.1016/j.jdent.2015.08.014

Cited by 21 publications

(35 citation statements)

References 43 publications

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“…According to recent studies, the incorporation of Halloysite ® nanotubes (HNTs) into dentin adhesives improves the adhesive's mechanical properties and also serves as a reservoir for the sustained release of therapeutic agents. [18][19][20][21][22] Thus, the purpose of this study was to fine-tune the nanotube loading method by adding CHX at distinct concentrations and evaluate whether the addition of CHX-loaded nanotubes would affect the physicochemical, mechanical, and biological properties of the adhesives.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and biological properties of novel chlorhexidine‐loaded nanotube‐modified dentin adhesive

et al. 2018

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A commercially available three-step (etch-and-rinse) adhesive was modified by adding chlorhexidine (CHX)-loaded nanotubes (Halloysite®, HNT) at two concentrations (CHX10% and CHX20%). The experimental groups were: SBMP (unmodified adhesive, control), HNT (SBMP modified with HNT), CHX10 (SBMP modified with HNT loaded with CHX10%), and CHX20 (SBMP modified with HNT loaded with CHX20%). Changes in the degree of conversion (DC%), Knoop hardness (KHN), water sorption (WS), solubility (SL), antimicrobial activity, cytotoxicity, and anti-matrix metalloproteinase [MMP-1] activity (collagenase-I) were evaluated. In regards to DC%, two-way ANOVA followed by Tukey's post-hoc test revealed that only the factor "adhesive" was statistically significant (p < 0.05). No significant differences were detected in DC% when 20 s light-curing was used (p > 0.05). For Knoop microhardness, one-way ANOVA followed by the Tukey's test showed statistically significant differences when comparing HNT (20.82 ± 1.65) and CHX20% (21.71 ± 2.83) with the SBMP and CHX10% groups. All adhesives presented similar WS and cytocompatibility. The CHX-loaded nanotube-modified adhesive released enough CHX to inhibit the growth of S. mutans and L. casei. Adhesive eluates were not able to effectively inhibit MMP-1 activity. The evaluation of higher CHX concentrations might be necessary to provide an effective and predictable MMP inhibition. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res B Part B, 2018.

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Section: Introductionmentioning

confidence: 99%

Physicochemical and biological properties of novel chlorhexidine‐loaded nanotube‐modified dentin adhesive

et al. 2018

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“…Recent studies have demonstrated that the incorporation of HNTs (5 wt.%) in resin-based materials (i.e., dental adhesive systems and enamel infiltrants) could improve their micro-hardness, flexural strength [ 15 ] and maximum polymerization rate [ 11 ]. However, if the concentration of HNTs is higher than 10 wt.% it is likely to attain a decrease of both flexural strength [ 15 ] and maximum polymerization rate [ 11 ]. The reason of such outcomes has been attributed to the behavior of such nanotubes to agglomerate in micro-cluster; this causes interference in the mechanism of interaction between nanotubes and the polymer matrix [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Halloysite nanotubes (HNT) are natural aluminosilicates with a hollow tubular structure [ 3 ], which are typically used as a reinforcing nano-filler to improve some mechanical properties of resin-composites [ 15 ] such as tensile strength, flexural strength, storage modulus [ 16 ], as well as microhardness and bond strength [ 17 ]. HNT is a “green” biocompatible nanomaterial characterized by very low cytotoxicity [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…HNT is a “green” biocompatible nanomaterial characterized by very low cytotoxicity [ 18 ]. Furthermore, it acts as “biologically-safe” reservoirs for the encapsulation and controlled release of a variety of therapeutic drugs [ 15 , 19 ], bioactive molecules [ 20 ] and matrix metalloproteinase inhibitors [ 21 , 22 ]. Active principles released by halloysite may last 30 to 100 times more than when these were incorporated alone or using some different nanocarriers in polymer nanocomposite [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical and Microbiological Assessment of an Experimental Composite Doped with Triclosan-Loaded Halloysite Nanotubes

et al. 2018

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This study is aimed at evaluating the effects of triclosan-encapsulated halloysite nanotubes (HNT/TCN) on the physicochemical and microbiological properties of an experimental dental composite. A resin composite doped with HNT/TCN (8% w/w), a control resin composite without nanotubes (HNT/TCN-0%) and a commercial nanofilled resin (CN) were assessed for degree of conversion (DC), flexural strength (FS), flexural modulus (FM), polymerization stress (PS), dynamic thermomechanical (DMA) and thermogravimetric analysis (TGA). The antibacterial properties (M) were also evaluated using a 5-day biofilm assay (CFU/mL). Data was submitted to one-way ANOVA and Tukey tests. There was no significant statistical difference in DC, FM and RU between the tested composites (p > 0.05). The FS and CN values attained with the HNT/TCN composite were higher (p < 0.05) than those obtained with the HNT/TCN-0%. The DMA analysis showed significant differences in the TAN δ (p = 0.006) and Tg (p = 0) between the groups. TGA curves showed significant differences between the groups in terms of degradation (p = 0.046) and weight loss (p = 0.317). The addition of HNT/TCN induced higher PS, although no significant antimicrobial effect was observed (p = 0.977) between the groups for CFUs and (p = 0.557) dry weight. The incorporation of HNT/TCN showed improvements in physicochemical and mechanical properties of resin composites. Such material may represent an alternative choice for therapeutic restorative treatments, although no significance was found in terms of antibacterial properties. However, it is possible that current antibacterial tests, as the one used in this laboratory study, may not be totally appropriate for the evaluation of resin composites, unless accompanied with aging protocols (e.g., thermocycling and load cycling) that allow the release of therapeutic agents incorporated in such materials.

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“…Nanotubes are a hexagonal network of carbon atoms rolled up to form cylindrical nanostructures that may be extremely strong and stiff, displaying both excellent thermal and electrical properties (78). It is worth mentioning that nanotubes were recently shown to reinforce adhesive resins and thus resin-dentin bonds (79–81). The incorporation of nanotubes up to 20 wt.% in etch-and-rinse and up to 10 wt.% in self-etch adhesives showed increased bond strength results compared to experimental controls (79).…”

Section: Resin Matrix Reinforcement With Fillers And/or Remineralizinmentioning

confidence: 99%

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

Münchow

Bottino

2017

Curr Oral Health Rep

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Purpose of review To present an overview on the main agents (i.e., biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding. Recent findings According to studies retrieved for full text reading (2014–2017), there are currently six major strategies available to overcome resin-dentin bond degradation: (i) use of collagen crosslinking agents, which may form stable covalent bonds with collagen fibrils, thus strengthening the hybrid layer; (ii) use of antioxidants, which may allow further polymerization reactions over time; (iii) use of protease inhibitors, which may inhibit or inactivate metalloproteinases; (iv) modification of the bonding procedure, which may be performed by using the ethanol wet-bonding technique or by applying an additional adhesive (hydrophobic) coating, thereby strengthening the hybrid layer; (v) laser treatment of the substrate prior to bonding, which may cause specific topographic changes in the surface of dental substrates, increasing bonding efficacy; and (vi) reinforcement of the resin matrix with inorganic fillers and/or remineralizing agents, which may positively enhance physico-mechanical properties of the hybrid layer. Summary With the present review, we contributed to the better understanding of adhesion concepts and mechanisms of resin-dentin bond degradation, showing the current prospects available to solve that problematic. Also, adhesively-bonded restorations may be benefited by the use of some biomolecules, nanocompounds or alternative bonding strategies in order to minimize bond strength degradation.

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Synthesis and characterization of novel halloysite-incorporated adhesive resins

Cited by 21 publications

References 43 publications

Physicochemical and biological properties of novel chlorhexidine‐loaded nanotube‐modified dentin adhesive

Physicochemical and biological properties of novel chlorhexidine‐loaded nanotube‐modified dentin adhesive

Physicochemical and Microbiological Assessment of an Experimental Composite Doped with Triclosan-Loaded Halloysite Nanotubes

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

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