Synthesis and characterization of novel molecularly imprinted polymer – coated Mn-doped ZnS quantum dots for specific fluorescent recognition of cocaine

Chantada-Vázquez, María Del Pilar; Sánchez–González, Juan; Peña‐Vázquez, Elena; Tabernero, María Jesús; Bermejo, Ana María; Bermejo-Barrera, Pilar; Moreda-Piñeiro, Antonio

doi:10.1016/j.bios.2015.08.022

Cited by 79 publications

(30 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since MIPs are cost-effective and robust materials, they have been extensively used in many fields such as an adsorbent material [21], solid phase microextraction [22][23][24] and chemosensors and biosensors [25][26][27]. For sensor applications, the composite fluorescence probes using QDs incorporated into MIPs have been developed as highly selective fluorescence probes for the determination of some target compounds such as salbutamol [28], patulin [29], sulfadiazine [30], sulfadimidine [31], malachite green [32], tetracycline [33], cocaine [34] and amoxicillin [35]. To improve the kinetic adsorption or affinity binding of ciprofloxacin, addition of carboxylic acid functionalized multiwall carbon nanotubes is an interesting alternative approach since they contain an extended  structure which can adsorb aromatic compounds via - interactions [36].…”

Section: Introductionmentioning

confidence: 99%

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

Yuphintharakun

Nurerk

Chullasat

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

View full text Add to dashboard Cite

A nanocomposite optosensor consisting of carboxylic acid functionalized multiwall carbon nanotubes and CdTe quantum dots embedded inside a molecularly imprinted polymer (COOH@MWCNT-MIP-QDs) was developed for trace ciprofloxacin detection. The COOH@MWCNT-MIP-QDs were synthesized through a facile sol-gel process using ciprofloxacin as a template molecule, 3-aminopropylethoxysilane as a functional monomer and tetraethoxysilane as a cross-linker at a molar ratio of 1:8:20. The synthesized nanocomposite optosensor had high sensitivity, excellent specificity and high binding affinity to ciprofloxacin. Under optimal conditions, the fluorescence intensity of the optosensor decreased in a linear fashion with the concentration of ciprofloxacin and two linear dynamic ranges were obtained, 0.10-1.0 μg L and 1.0-100.0 μg L with a very low limit of detection of 0.066 μg L. The imprinting factors of the two linear range were 17.67 and 4.28, respectively. The developed nanocomposite fluorescence probe was applied towards the determination of ciprofloxacin levels in chicken muscle and milk samples with satisfactory recoveries being obtained in the range of 82.6 to 98.4%. The results were also in good agreement with a HPLC method which indicates that the optosensor can be used as a sensitive, selective and rapid method to detect ciprofloxacin in chicken and milk samples.

show abstract

Section: Introductionmentioning

confidence: 99%

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

Yuphintharakun

Nurerk

Chullasat

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

View full text Add to dashboard Cite

show abstract

“…Compared with organic fluorescent dye, QDs are more photostable and can exhibit strong luminescence, wide excitation but sharp emission profile, which are size-dependent (Silvi and Credi, 2015). The most well-known QDs embedded in MI-FL sensors are cadmium (Cd) (Huy et al, 2014;Liu et al, 2014b) and zinc (Zn) based (Chantada-Vázquez et al, 2016;Chen et al, 2017a;Li et al, 2017a;Zhang et al, 2018), and as we know, QDs synthesized using hydrophobic ligands such as trioctyl phosphine oxide (TOPO) can endow QDs with excellent quantum yield and chemical stability, but limit their hydrophilic applications. Using a reverse microemulsion polymerization, Liu et al (2014b) embedded the hydrophobic TOPO-modified CdSe QDs into the MI-FL sensor using cyclohexane as a continuous phase and Triton X-100 as a surfactant, obtaining both high quantum yield and hydrophilic applicability for ractopamine detection.…”

Section: Embedding Of Fluorescence Substancesmentioning

confidence: 99%

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Yang

Wang

et al. 2018

Biosensors and Bioelectronics

327

126

View full text Add to dashboard Cite

One pressing concern today is to construct sensors that can withstand various disturbances for highly selective and sensitive detecting trace analytes in complicated samples. Molecularly imprinted polymers (MIPs) with tailor-made binding sites are preferred to be recognition elements in sensors for effective targets detection, and fluorescence measurement assists in highly sensitive detection and user-friendly control. Accordingly, molecular imprinting-based fluorescence sensors (MI-FL sensors) have attracted great research interest in many fields such as chemical and biological analysis. Herein, we comprehensively review the recent advances in MI-FL sensors construction and applications, giving insights on sensing principles and signal transduction mechanisms, focusing on general construction strategies for intrinsically fluorescent or nonfluorescent analytes and improvement strategies in sensing performance, particularly in sensitivity. Construction strategies are well overviewed, mainly including the traditional indirect methods of competitive binding against pre-bound fluorescent indicators, employment of fluorescent functional monomers and embedding of fluorescence substances, and novel rational designs of hierarchical architecture (core-shell/hollow and mesoporous structures), post-imprinting modification, and ratiometric fluorescence detection. Furthermore, MI-FL sensor based microdevices are discussed, involving micromotors, test strips and microfluidics, which are more portable for rapid point-of-care detection and in-field diagnosing. Finally, the current challenges and future perspectives of MI-FL sensors are proposed.

show abstract

“…Currently, MIPs participate in a diversity of applications such as solid‐phase extraction (SPE), chemical sensing, catalysis, and drug delivery . Specifically, MIP‐based fluorescence (MIP‐FL) probes have been of great interest for optical sensing systems due to their excellent selectivity and fluorescent stability . To date, AuNCs, AgNCs, and CuNCs have been used to manufacture MIP‐FL probes.…”

Section: Introductionmentioning

confidence: 99%

Selective Detection of Trace Metronidazole by Using a Magnetic Molecularly Imprinted Polymer‐based Fluorescent Probe

Tan

Lan

Yin

et al. 2019

Bulletin Korean Chem Soc

View full text Add to dashboard Cite

A magnetic molecularly imprinted polymer-based fluorescent (MIP-FL) probe has been synthesized by embedding glutathione-stabilized gold nanoclusters (GSH-AuNCs) and Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) into silica composites. The Fe 3 O 4 NPs/AuNCs@MIPs are characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and UV-Vis absorption spectroscopy. The results show that the spherical Fe 3 O 4 NPs/AuNCs@MIPs contain a core-shell structure with GSH-AuNCs anchored on the surface of silica-protected Fe 3 O 4 NPs. As a fluorescence probe (excitation: 360 nm, emission: 615 nm), Fe 3 O 4 NPs/AuNCs@MIPs can selectively detect metronidazole (MNZ) among other nitroimidazoles (ronidazole, ornidazole, and tinidazole). During the detection, the fluorescence intensity of the MIP-FL probe drops gradually with increasing MNZ concentration. The sensitive linear range of the fluorescence probe is from 0 to 5 μM, and the limit of detection is 4.2 nM. After the recognition sites interact with the template, the occurrence of charge transfer from the GSH-AuNCs to MNZ results in fluorescence quenching. Finally, a real sample test has been performed in spiked milk. Satisfactory recoveries spanning from 96% to 102% indicate that Fe 3 O 4 NPs/AuNCs@MIPs enable highly sensitive detection of MNZ based on fluorescence signal output, while the MIPs also have enrichment potential for the target from complex samples due to the magnetic properties.

show abstract

Synthesis and characterization of novel molecularly imprinted polymer – coated Mn-doped ZnS quantum dots for specific fluorescent recognition of cocaine

Cited by 79 publications

References 24 publications

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Selective Detection of Trace Metronidazole by Using a Magnetic Molecularly Imprinted Polymer‐based Fluorescent Probe

Contact Info

Product

Resources

About