Synthesis and characterization of novel blue-emitting nicotinamide-gold nanoclusters with “chain-breaker” antioxidant property

Synthesis and characterization of fluorescent gold clusters encapsulated in PNIPAM and PAAM hydrogels for selective detection of mercury in water

“…Several research studies had demonstrated that the AuNCs fluorescence depends on the pH. 48–50 In that sense Csapó et al 48 shows that the nicotinamide-stabilized AuNCs present detectable fluorescence in the pH range 1–12, showing a fluorescence decrease at pH < 3.0 and pH > 10.0. Moreover, the decreasing of the fluorescence a low pH is attributed to the formation of aggregates of NAM-Au NCs and at high pH the clusters lose their stability again thanks to the high electrostatic shielding.…”

Promising Bioactivity of Vitamin B1-Au Nanocluster: Structure, Enhanced Antioxidant Behavior, and Serum Protein Interaction

“…It is well known that the Vitamin B molecular family shows an excellent antioxidant effect [ 45 ]. In our previous study, it was shown that the Vitamin B 3 derivative niacinamide, after the synthesis of Au NCs, is still usable as an antioxidant agent (ORAC value for B 3 (amide) = 0.56 µM, for B 3 (amide)-Au NCs = 0.48 µM) [ 46 ]. Thiamine shows a larger preventive effect against ROS with a chain breaker mechanism [ 47 ], because the antioxidant can donate an electron and a proton to ROS at the same time, which annihilates the harmful effect of ROS on the chemical environment.…”

“…The confirmation of the potential bioactivity was also investigated by comparisons with previously prepared antioxidant niacinamide-stabilized Au NCs (NAM-Au NCs) [ 46 ]. As can be seen on Figure 5 , the interaction with the serum protein dramatically depends on the chemical structure of the stabilizing molecule of the metal surface.…”

Thermodynamic Characterization of the Interaction of Biofunctionalized Gold Nanoclusters with Serum Albumin Using Two- and Three-Dimensional Methods

“…In recent years, the simple, one-pot, "green" syntheses of protein-stabilized AuNCs have been published in numerous works, where it has been proven that the structure of the synthesized nano-object fundamentally depends on the molar ratio of the precursor and the protein. Besides the protein-protected Au clusters, especially small bioligands (e.g., vitamins [5], nucleotides [6], amino-and hydroxamic acids [7,8]), stabilized AuNCs have appeared in the scientific literature as a new class of nanomaterials with great promise in bio-labeling [9], -sensing [10], and -imaging [11,12], as well as targeted cancer therapy applications [13,14].…”

“…The production and purification of metal nanoclusters stabilized with small molecules were based on the recipes and methods presented in the research group's relevant publications [5,6,25]. During the synthesis of nicotinamide (NAM) [6], thiamine hydrochloride (TIA) [5], and adenosine monophosphate (AMP) [25] stabilized gold nanoclusters (AuNCs), a cluster dispersion with a volume of 15 cm 3 was uniformly produced. Then, before using the aqueous colloidal systems for further investigations, the ligand and precursor metal salt remaining in the supernatant were removed by dialysis.…”