Synthesis and characterization of ordered mesoporous silica containing di-ureasil hybrid/phosphotungstic acid and Eu3+

Cavalcante, Cleusa; Molina, C.; Martins, Tereza Silva

doi:10.1007/s10854-019-01626-0

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Conclusões E Perspectivas Futuras1

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2024

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Cited by 4 publications

(1 citation statement)

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“…A síntese de partículas de SBA-15 foi bem-sucedida, conforme mostram os parâmetros morfológicos, estruturais e texturais em alta conformidade com trabalhos reportados para o mesmo protocolo de síntese (OJEDA-LÓPEZ et al, 2015;CAVALCANTE;MOLINA;MARTINS, 2019). Durante o procedimento de incorporação da proteína em SBA-15, notou-se a formação de agregados que podem estar relacionados à concentração proteica utilizada (6 mg/mL).…”

Section: Conclusões E Perspectivas Futurasunclassified

Estudos estruturais de proteínas incorporadas em sílica mesoporosa ordenada

Pedro

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Section: Conclusões E Perspectivas Futurasunclassified

Estudos estruturais de proteínas incorporadas em sílica mesoporosa ordenada

Pedro

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Ordered mesoporous silicas for potential applications in solid vaccine formulations

Miranda,

Nunes,

Santos

et al. 2024

Vaccine

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Oral vaccination of piglets against Mycoplasma hyopneumoniae using silica SBA-15 as an adjuvant effectively reduced consolidation lung lesions at slaughter

Mechler-Dreibi

Almeida

Sonálio

et al. 2021

Sci Rep

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Mycoplasma (M.) hyopneumoniae is the main pathogen of porcine enzootic pneumonia (PEP). Its controlling is challenging, and requires alternative strategies. This study aimed to develop an oral vaccine against M. hyopneumoniae using a nanostructured mesoporous silica (SBA-15) as an adjuvant, and compare its effect with an intramuscular (IM) commercial vaccine (CV). Fifty 24 day-old M. hyopneumoniae-free piglets composed five equal groups for different immunization protocols, consisting of a CV and/or oral immunization (OI). Control piglets did not receive any form of immunization. All piglets were challenged with M. hyopneumoniae strain 232 on D49 by tracheal route. IgA antibody response in the respiratory tract, bacterial shedding and serum IgG were evaluated. The piglets were euthanized on 28 (D77) and 56 (D105) days post-infection. Lung lesions were macroscopically evaluated; lung fragments and bronchoalveolar fluid (BALF) were collected for estimation of bacterial loads by qPCR and/or histopathology examination. All immunization protocols induced reduction on Mycoplasma-like macroscopic lung lesions. IgA Ab responses anti-M. hyopneumoniae, the expression of IL-4 cytokine and a lower expression of IL-8 were induced by CV and OI vaccines, while IgG was induced only by CV. Oral immunization using silica as a carrier-adjuvant can be viable in controlling M. hyopneumoniae infection.

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Synthesis and characterization of ordered mesoporous silica containing di-ureasil hybrid/phosphotungstic acid and Eu3+

Cited by 4 publications

References 25 publications

Estudos estruturais de proteínas incorporadas em sílica mesoporosa ordenada

Estudos estruturais de proteínas incorporadas em sílica mesoporosa ordenada

Ordered mesoporous silicas for potential applications in solid vaccine formulations

Oral vaccination of piglets against Mycoplasma hyopneumoniae using silica SBA-15 as an adjuvant effectively reduced consolidation lung lesions at slaughter

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