Synthesis and characterization of partially biodegradable, temperature and pH sensitive Dex–MA/PNIPAAm hydrogels

Zhang, Xian‐Zheng; Wu, Daqing; Chu, Chih‐Chang

doi:10.1016/j.biomaterials.2003.11.040

Cited by 208 publications

(135 citation statements)

References 48 publications

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“…The resulting hydrogel was partially biodegradable and exhibited a higher LCST than pNiPAAm due to the hydrophilic and biodegradable nature of Dex-MA. Additionally, the carboxylic end groups of Dex-MA render the hydrogel pH sensitive [30]. Another approach based on a dextran polysaccharide was reported by Huang et al [31].…”

Section: 13mentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,135

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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Section: 13mentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,135

696

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“…Within pH-responsive systems, poly(N-isopropylacrylamide) (PNIPAm) is perhaps the most studied polymer [18][19][20][21][22] . These are network-like systems that contain pH-dependent ionizable groups.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Echeverría¹,

Pardini²,

Debandi

et al. 2015

Polímeros

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SbstractA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.

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“…Non-laser-based techniques are intensively used to fabricate thin films and hydrogels as well [123][124][125]. The influence of Dextran and albumin-derived iron oxide nanoparticles on fibroblasts in vitro was studied by Berry et al [126].…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic-inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries' synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.

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Synthesis and characterization of partially biodegradable, temperature and pH sensitive Dex–MA/PNIPAAm hydrogels

Cited by 208 publications

References 48 publications

Thermoresponsive hydrogels in biomedical applications

Thermoresponsive hydrogels in biomedical applications

Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

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