Synthesis and characterization of pectin/SiO2 hybrid materials

Rangelova, Nadezhda; Александров, Л. Н.; Nenkova, S.

doi:10.1007/s10971-017-4556-z

Cited by 36 publications

(13 citation statements)

References 59 publications

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“…The obtained nanoformulation, as well as all the components of the top phase, were analyzed through FTIR spectroscopy to investigate the effect of SiO2, and the resulting spectrum is presented in Figure 3. In the bare SiO2 spectrum, before water exposure, the peaks at 473, 798, and 1110 cm -1 are related to the siloxane network (Si-O-Si), and the peaks at 963 and 3670 cm -1 are assigned to silanol groups (SiOH) and hydrogen bonding in the silanol group, respectively 51,56,76,77 . The SiO2 surface contains SiOH at room temperature, and it can be effectively hydroxylated in the presence of water and can form hydrogen bonding 51,56,78 .…”

Section: Ftir Analysismentioning

confidence: 99%

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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Providing an efficient system for drug delivery and chemotherapy has always been an important issue. Modification of the surface of silica nanoparticles (SiO2) provides an opportunity for achieving stimulus-sensitive drug delivery system. Here, we have modified the surface of SiO2 using hydrogen bonding interactions by employing an aqueous two-phase system (ATPS) based on polyethylene glycol and lysine. This novel biocompatible ATPS provides an environment for simultaneous drug encapsulation, SiO2 modification, and drug partitioning in one pot. Addition of SiO2 to ATPS increased the partitioning of doxorubicin (DOX) as an anti-cancer drug from 47.92 in the absence of nanoparticles to 92.33 due to the interactions between drug and nanoparticles. The formation of nanoformulation and its characteristics were investigated applying microscopy, spectroscopy and thermal analysis. Drug release study demonstrated that DOX is loaded on nanoformulations efficiently with an encapsulation efficiency of 63.84% and shows lower release in physiological environment compared to the unmodified nanoparticles. While in acidic conditions of pH 5.5, significant increase was observed in the release profile. MTT assay on MCF-7 cancer cells confirmed that the nanoformulations were non-toxic and DOX-loaded nanocarrier showed anti-cancer behavior. These results indicate that the prepared nanoformulations are promising nanocarriers for controlled drug release purposes.

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Section: Ftir Analysismentioning

confidence: 99%

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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“…To elucidate the molecular interactions of both PEC and CH with MSNs, all films were also analyzed by the ATR-FT-IR ( Figure 2). The bands detected in the region below 1,000 cm -1 arose from inter-atomic vibrations, the bands around 832 and 400 cm −1 , being characteristic of the silanol groups (Si-OH), and being related to the Si-O stretching and deformation frequencies [21,22]. The spectra of all PEC-based films (Figure 2, panel A) results were quite similar, representing bands originating from the vibrations of the functional groups of the compounds existing in their matrices, and showing only some differences in the relative intensities and positions.…”

Section: Film Ft-ir Analysesmentioning

confidence: 99%

Effect of Mesoporous Silica Nanoparticles on Glycerol-Plasticized Anionic and Cationic Polysaccharide Edible Films

et al. 2019

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This study describes the production of reinforced polysaccharide (PS)-based films, by adding mesoporous silica nanoparticles (MSNs), to either pectin (PEC) or chitosan (CH) film forming solutions, either containing glycerol (GLY) as a plasticizer, or not. Film characterization demonstrated that MSNs and GLY were able to significantly increase the plasticity of both PS-based biomaterials and that the interactions between PSs and nanoparticles were mainly due to hydrogen bonds. Moreover, MSN-containing films were less transparent, compared to controls prepared with either PEC or CH, in the absence of GLY, while all films containing MSNs, but obtained with the plasticizer, were as transparent as the films prepared with PEC or CH alone. MSN addition did not influence the thickness of the PEC-based films, but increased that of CH-based ones, prepared both in the absence and presence of GLY. MSN-containing PEC-based films possessed a more compact and homogeneous morphology, with respect to both control films, prepared, with or without GLY, and to the CH-based films, containing MSNs, the structure of which showed numerous agglomerations. Finally, moisture content and uptake were reduced, in all films prepared in the presence of MSNs. The suggested addition of MSNs might have given rise to novel biomaterials for food or pharmaceutical applications.

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“…Moreover, Tyagi et al [24], demonstrated that the incorporation of silica with polysaccharide has a significant reduction to the rate of water vapor transmission and water vapor permeability of the film. However, amorphous hybrids materials with the participation of pectin and silica derived from aqueous silicates and tetraethoxysilane (TEOS) were successfully prepared [25,26].…”

Section: Introductionmentioning

confidence: 99%

Effect of Mesoporous Silica Nanoparticles on The Physicochemical Properties of Pectin Packaging Material for Strawberry Wrapping

et al. 2019

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Citrus peel pectin was used to prepare films (cast with or without glycerol) containing mesoporous silica nanoparticles. Nanoparticles reduced significantly the particle size, and had no effect on the Zeta potential of pectin solutions. Mechanical characterization demonstrates that pectin+nanoparticles containing films slightly increased tensile strength and significantly decreased the Young’s modulus in comparison to films made only of pectin. However, elongation at the break increased in the pectin+nanoparticles films cast in the presence of glycerol, while both Young’s modulus and tensile strength were reduced. Moreover, nanoparticles were able to reduce the barrier properties of pectin films prepared with or without glycerol, whereas positively affected the thermal stability of pectin films and the seal strength. The 0.6% pectin films reinforced or not with 3% nanoparticles in the presence of 30% glycerol were used to wrap strawberries in order to extend the fruit’s shelf-life, over a period of eighty days, by improving their physicochemical properties.

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Synthesis and characterization of pectin/SiO2 hybrid materials

Cited by 36 publications

References 59 publications

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Effect of Mesoporous Silica Nanoparticles on Glycerol-Plasticized Anionic and Cationic Polysaccharide Edible Films

Effect of Mesoporous Silica Nanoparticles on The Physicochemical Properties of Pectin Packaging Material for Strawberry Wrapping

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