Synthesis and characterization of PEGylated iron and graphene oxide magnetic composite for curcumin delivery

Abstract

Nowadays, nanostructures have been given significant attention in medical and biological fields. Among these nanostructures, graphene oxide (GO) has been widely used in drug delivery systems, because of its unique properties, and the ability to connect to other nanostructures such as magnetic nanoparticles (NPs) as well as polymers by its functional groups. In this research, first, GO was prepared by exfoliating graphite according to the modified Hummer’s method, and then the Fe3O4 NPs were synthesized by a simple co‐precipitation method on GO nanosheets. In the next step, with the help of the ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide/N‐hydroxysuccinimide coupling reagents, the polyethylene glycol (PEG) polymer was bonded to the GO‐Fe3O4 nanocomposite. Finally, anti‐cancer drug, curcumin (Cur) was loaded onto the nanocomposite and the Cur loading ratio was measured at about 8%. The samples were evaluated using Fourier transform‐infrared, differential scanning calorimtery, vibrating‐sample magnetometry, atomic force microscopy and dynamic light scattering techniques. The results show that the prepared nanocomposite is an appropriate candidate for biomedical applications.

The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

“…Curcumin (CUR) is a natural remedy and the main components of the turmeric spice, which has antioxidant, anti-in ammatory properties and is a liposoluble compound and can be easily dissolved into the organic solvent such as methanol, ethanol and acetone [21]. Also owning to the preclinical data that shows anticancer property of curcumin, it has concerned signi cant attention in drug delivery systems for cancer research [22][23][24]. In 2017, Xie and its colleagues developed nanoparticles containing the anticancer drug of curcumin for chemotherapy and photothermal therapy of cancer, as well as to protect normal cells.…”