Synthesis and Characterization of pH- and Temperature-sensitive Hydrogels of Poly (Styrene-alt-Maleic Anhydride)-co-Pluronic for Drug Release

Abstract

The effect of proportions between PMSA and P123 on the gel fraction was determined. The effects of pH value and temperature on swelling ratio of the hydrogels were evaluated. Scanning electron microscopy was used to observe the morphology of the hydrogels. Differential scanning calorimetry was employed to characterize the thermo-sensitivity of the hydrogel. The drug-release behavior of the hydrogels was investigated by using chloromycetin as a model drug. The effect of temperature and pH on the release of chloromycetin from the hydrogels was studied. These results showed that PSMA-P123 hydrogels, being pH-and temperature-sensitive and reversible, appeared to be of potential for biomedical materials, especially for drug release applications.

Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery

“…Poly­(styrene- co -maleic anhydride-acrylic acid) (Figure ) has been used to prepare porous membranes that can bind to an enzyme and act as enzyme reactor . A copolymer with pluronic (also known as poloxamers, triblock PEO–PPO–PEO copolymers of hydrophilic poly­(ethylene oxide) (PEO) and hydrophobic poly­(propylene oxide (PPO)) has been synthesized and characterized to obtain temperature-sensitive hydrogels . PSMA copolymer could also be blended with poly­(ether sulfone) to prepare hollow fiber membranes .…”

“…56 A copolymer with pluronic (also known as poloxamers, triblock PEO−PPO− PEO copolymers of hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(propylene oxide (PPO)) has been synthesized and characterized to obtain temperature-sensitive hydrogels. 57 PSMA copolymer could also be blended with poly(ether sulfone) to prepare hollow fiber membranes. 58 The same concept was used with a poly(acrylonitrile-co-maleic anhydride) 59 and poly(methyl methacrylate-co-maleic anhydride).…”

On the Effects of UV Radiation on the Release Ability of Glucose Embedded in Hydroxypropyl Cellulose Films

“…In pharmaceutics, HPC is utilized as a topical ophthalmic protection and lubricant, thickener, emulsion stabilizer and as a binder for the wet granulation method of making tablets. [9] The reasons for its widespread acceptance include (1) great solubility characteristics in gastrointestinal and other organic fluids, (2) non-interference with tablet disintegration and drug availability, (3) flexibility, chip resistance and absence of taste and odor, (4) stability in the presence of heat, light, air or reasonable levels of moisture, and (5) ability to incorporate color and other additives into the film or tablet without difficulty. The HPC good solubility in most polar organic solvents makes it possible to prepare stable aqueous and nonaqueous solutions [10] thus forming thermotropic as well as lyotropic liquid crystalline phases in many solvents [11] .…”

“…[1][2][3] Such materials can be utilized for controlled release of both water-soluble and insoluble drugs. [4] Since the polymer is the most critical component of a controlled release tablet, which through its unique physiochemical characteristics determines a certain rate release, it has gained importance in pharmaceutical applications both as drug encapsulant and drug carrier.…”