Synthesis and characterization of photodynamic activity of an iodinated Chlorin p₆copper complex

Abstract

A novel iodinated copper complex of Chlorinp6that acts as type I photosensitizer and capable of inducing phototoxicity in cancer cells under hypoxia.

Self-assembly of chlorin-e6 on γ-Fe2O3 nanoparticles: Application for larvicidal activity against Aedes aegypti

“…4, panel B). A similar appearance of FTIR bands in the CeO stretching region of chlorin-e6 was already described upon chelation of metal ions in solution [55], further confirming the formation of a metal complex of the photosensitizer [56].…”

Enhancement of radiosensitivity of oral carcinoma cells by iodinated chlorinp6copper complex in combination with synchrotron X-ray radiation

“…ICp 6 -Cu is a novel chlorophyll-based PS recently reported by us for potential application in the PDT of cancer (Sarbadhikary et al, 2016). The motivation to synthesize ICp 6 -Cu was to exploit the tumor-localizing property of chlorin for multi-modal cancer therapy.…”

“…Recently, we have reported a novel metal complex of chlorin p 6 referred to as iodinated chlorin p 6 copper complex (ICp 6 -Cu) for potential use in PDT of cancer. ICp 6 -Cu demonstrated pronounced photodynamic activity via freeradical generation and induced potent phototoxic effect against cancer cells under both normoxic and hypoxic conditions (Sarbadhikary et al, 2016). The presence of copper and iodine in ICp 6 -Cu makes it suitable for X-ray photoactivation using an X-ray energy of !…”

Potential Application of Photosensitizers With High-Z Elements for Synergic Cancer Therapy

“…For chlorophyll derivatives, chlorin e6 and pheophorbide, insertion of Sn 2+ , Pd 2+ , and Cu 2+ cause ~15 nm blue shift in the Q band whereas in case of Zn 2+ the blue shift was only few nm (O'Connor et al, 2009;Yoon et al, 2011;Dąbrowski et al, 2016). The effect is not only observed with the centrally coordinated metal complexes but also observed with ICp6-Cu, where the coordination of Cu 2+ to the peripheral carboxylic groups resulted in ~29 nm shift in the Q absorption band at 634 nm from 663 nm for metal-free Cp6 (Sarbadhikary et al, 2016). Ru (II) ions inserted in the porphyrin core have Q absorption bands in the wavelength region between 500-550 nm (Bogoeva et al, 2016).…”

“…Yet another iodinated chlorin p6 copper complex (ICp6–Cu) demonstrated its PDT efficacy against oral cancer cells inducing 90% phototoxicity with 10 μM concentration irradiated with 630 nm at 12 J/cm 2 . Importantly, this complex showed to act predominantly through the type I photochemical process, with the efficacy to induce phototoxicity even under hypoxic conditions ( Sarbadhikary et al, 2016 ).…”