Synthesis and characterization of poly(acryloxyethyl‐trimethylammonium chloride‐co‐2‐hydroxyethyl methacrylate): A study of its interaction with sodium alginate

Abstract

Poly(acryloxyethyl-trimethylammonium chloride-co-2-hydroxyethyl methacrylate) [poly(Q-co-H)] was prepared by free radical polymerization in aqueous solution at 608C using potassium persulfate as initiator. Spectroscopic characterization confirmed the formation of poly(Q-co-H) and the molar fractions of acryloxyethyl-trimethylammonium chloride monomer units incorporated in the copolymers were determined by potenciometric titrations. The monomer reactivity ratios for Q and H are found to be r Q 5 0.04 6 0.01 and r H 5 3.22 6 0.84 using Fineman-Rö ss method and r Q 5 0.06 and r H 5 3.61 using Genetic Algorithms method. Finally we studied reaction between poly(Q-co-H) and sodium alginate by conductimetric measurement.

Synthesis and characterization of polyelectrolyte complex microparticles for drug release

“…Thus, when the microparticles are placed in simulated fluid medium their inner sponge structure rapidly absorb fluid medium, facilitating Cefazolin diffusion and release. A similar morphology for alginate–chitosan microparticles was observed by Acosta et al37 and system reported in previous publication using SEM 24…”

“…For this purpose the feed monomer composition of Q/H = 95/5 wt %, that corresponds to 92/8 mol %, was used. Copolymerization of these two monomers was detailed investigated previously and it was shown that this ratio between Q and H was optimum for synthesis of the copolymer with the highest concentration of quaternary ammonium (cationic) units in the polymer chain 24,25…”

“…This hydrophilicity confers permeability of molecules and improve soft consistency which makes the matrix similar to the physical characteristic of living tissues. In previous manuscript we report growth goat mammary epithelial cells culture over microcapsules of Q 24,25. The combination of sodium alginate with this acrylic polymers could be a promote scaffold in biomedical application 12,24,25,26…”

A comparative study of two polyelectrolyte complexes

“…The poly(acryloxyethyl‐trimethylammonium chloride‐ co ‐2‐hydroxyethyl methacrylate) copolymer (poly(Q‐ co ‐H)) was prepared by free radical polymerization of the mixture of corresponding monomers (i.e., Q and H) in aqueous solution without the use of any crosslinking agent by a previously described procedure 15, 16. The polymerization was carried out for 48 h at 60°C that permitted to achieve high (>90%) conversions.…”

“…The hydrophilic permanently charged quaternary ammonium groups provide good water solubility, and the solution properties correspond to those of a strong polyelectrolyte 13, 14. Recently, poly(Q‐ co ‐H)/NaAlg complexes have been proposed as scaffolds for drug delivery and tissue regeneration 15, 17…”