Synthesis and characterization of poly(propylene imine) dendrimer – Polypyrrole conducting star copolymer

Baleg, Abd Almonam; Jahed, Nazeem; Arotiba, Omotayo A.; Mailu, Stephen N.; Hendricks, Nicolette R.; Baker, Priscilla; Iwuoha, Emmanuel I.

doi:10.1016/j.jelechem.2010.12.010

Cited by 19 publications

(9 citation statements)

References 40 publications

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“…The X‐ray diffractograms (XRD) of PPy‐PEI NPs are compared with PPy‐PEI‐P NCs in Figure e. It has been reported that PPy had a diffraction peak at around 25.0° with moderate intensity . However, PPy‐PEI NPs show a broad amorphous diffraction peak in a 2θ range of 12.5°–40.0°.…”

Section: Resultsmentioning

confidence: 99%

Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy

Burnouf

et al. 2017

Adv Healthcare Materials

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Cancer cells exhibit specific physiological differences compared to normal cells. Most surface membranes of cancer cells are characterized by high expression of given protein receptors, such as albumin, transferrin, and growth factors that are also present in the plasma of patients themselves, but are lacking on the surface of normal cells. These distinct features between cancer and normal cells can serve as a niche for developing specific treatment strategies. Near-infrared (NIR)-light-triggered therapy platforms are an interesting novel avenue for use in clinical nanomedicine. As a photothermal agent, conducting polymer nanoparticles, such as polypyrrole (PPy), of great NIR light photothermal effects and good biocompatibility, show promising applications in cancer treatments through the hyperthermia mechanism. Autologous plasma proteins coated PPy nanoparticles for hyperthermia therapy as a novel core technology platform to treat cancers through secreted protein acid and rich in cysteine targeting are developed here. This approach can provide unique features of specific targeting toward cancer cell surface markers and immune transparency to avoid recognition and attack by defense cells and achieve prolonged circulation half-life. This technology platform unveils new clinical options for treatment of cancer patients, supporting the emergence of innovative clinical products.

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Section: Resultsmentioning

confidence: 99%

Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy

Burnouf

et al. 2017

Adv Healthcare Materials

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“…This poly(propylenethiopheneimine)-co-poly(3,4-ethylenedioxythiophene) (G1PPT-co-PEDOT) demonstrated improved optical, electrical, and photophysical properties, desirable properties that may be beneficial for photovoltaics and optoelectronic devices. Baleg et al [60] modified poly(propylene imine) dendrimer by polymerizing pyrrole monomer units on the dendrimer principal core using (NH 4 ) 2 S 2 O 8 as an oxidizing agent in a solvent mixture of water and chloroform, which resulted in a conductive star copolymer. Hai et al [61] modi-fied polypropylene (PP) on the surface with P3HT via oxidative chemical polymerization using FeCl 3 dispersed in hexane (see Scheme 5).…”

Section: Oxidative Polymerizationsmentioning

confidence: 99%

π-Conjugated Polymers and Their Application in Organic and Hybrid Organic-Silicon Solar Cells

et al. 2022

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The evolution and emergence of organic solar cells and hybrid organic-silicon heterojunction solar cells have been deemed as promising sustainable future technologies, owing to the use of π-conjugated polymers. In this regard, the scope of this review article presents a comprehensive summary of the applications of π-conjugated polymers as hole transporting layers (HTLs) or emitters in both organic solar cells and organic-silicon hybrid heterojunction solar cells. The different techniques used to synthesize these polymers are discussed in detail, including their electronic band structure and doping mechanisms. The general architecture and principle of operating heterojunction solar cells is addressed. In both discussed solar cell types, incorporation of π-conjugated polymers as HTLs have seen a dramatic increase in efficiencies attained by these devices, owing to the high transmittance in the visible to near-infrared region, reduced carrier recombination, high conductivity, and high hole mobilities possessed by the p-type polymeric materials. However, these cells suffer from long-term stability due to photo-oxidation and parasitic absorptions at the anode interface that results in total degradation of the polymeric p-type materials. Although great progress has been seen in the incorporation of conjugated polymers in the various solar cell types, there is still a long way to go for cells incorporating polymeric materials to realize commercialization and large-scale industrial production due to the shortcomings in the stability of the polymers. This review therefore discusses the progress in using polymeric materials as HTLs in organic solar cells and hybrid organic-silicon heterojunction solar cells with the intention to provide insight on the quest of producing highly efficient but less expensive solar cells.

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“…Among them, dendrimers are synthesized using a repetitive reaction sequence that flows a very highly monodisperse polymer chemistry and by virtue of their stepby-step controlled synthesis called molecular chemistry. 13,28,33 The first approach, called the divergent method, was developed by Tomalia, in which the growth of dendrimers start from the core and grows outward, building generation by generation. 7,[30][31][32] Generally, there are two approaches for dendrimer synthesis.…”

Section: Synthesis and Properties Of Dendrimermentioning

confidence: 99%

PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents

2016

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In the last several decades, researchers have focused on developing suitable drug carriers to deliver pharmaceutical agents to treat cancer diseases. PAMAM dendrimers have been studied as potential delivery systems to targeting, imaging, and/or deliver therapeutic agents specifically to diseased tissues because of their unique properties, such as: multiple functionalities at the periphery or in the cavity, biocompatibility, tunable size, and monodispersity. Anti-cancer agents may be incorporated into the interior void space or conjugated to the surface of PAMAM to enhance the delivery of cytotoxic drugs. In addition, targeting ligands can also be attached to the dendrimer surface to allow active targeting and minimize harm to normal cells. In summary, this review highlights the contributions of PAMAM dendrimers to the field of nanotechnology with the intent to aid researchers in exploring dendrimers for targeted drug delivery, contrasting and bio-image agents. with specific ligands. 11 As previously reviewed, several polymeric nanocarriers can be prepared from both natural polymers, such as albumin, hyaluronic acid, and chitosan, and synthetic polymers, such as poly acrylamide (PAA), poly lactic acid (PLA), poly glycolic acid (PGA), poly(lactide-co-glycolide) (PLGA) and dendrimers. 12The purpose of this review is to provide readers an overview of well-defined PAMAM dendrimer nanomaterials which are available and may be of interest for cancer-related medical applications such as drug delivery and bio-imaging modalities. Therefore, the current review mainly focuses on the recent publications related to the development of PAMAM dendrimers for targeting and bio-imaging-guided drug delivery, as well as multifunctional dendrimer nanocomplexes. A brief introduction is also given for the in vitro and in vivo diagnosis of cancer and with a brief concluding remarks as well as future prospects of the topic. DendrimerDendrimers are a family of 3D nano-sized macromolecules exhibiting highly branched architecture initially reported by Fritz Vogtle in 1978 and synthesized by Donald Tomalia and George R. Newkome in the 1980s. [13][14][15] The name "dendrimer" comes from two Greek words dendron, which means "tree branch like", and meros, which means "part of", and was first discovered by Tomalia et al. 13 Dendrimer is considered as the fourth new class of polymer structure, that demonstrates significant application in nanomedicine including drug delivery due to its unique platform for the construction of various multifunctional carriers. 14, 16-23 Poly (amidoamine) (PAMAM) dendrimers are a family of highly branched and monodispersed synthetic macromolecules with well-defined structure and composition. 24, 25 These polymers have internal cavities and peripheral functional groups that can be modified to better localize

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Synthesis and characterization of poly(propylene imine) dendrimer – Polypyrrole conducting star copolymer

Cited by 19 publications

References 40 publications

Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy

Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy

π-Conjugated Polymers and Their Application in Organic and Hybrid Organic-Silicon Solar Cells

PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents

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