Synthesis and Characterization of Polysubstituted 5-Quinolinecarbaldehyde Derivatives

Synthesis and Transformation of 4‐(1‐Chloro‐1‐nitroethyl)‐6,7‐dimethoxy‐2‐methylquinazoline: Spectral Characterization and Anti‐cancer Properties of some Novel Quinazoline Derivatives

“…Quinazolines are stable in cold dilute acid and alkaline solutions, but it is destroyed when these solutions are boiled, [5] therefore the reaction of 6 with aromatic aldehydes (reaction h in Scheme 6) was carried out in ethanol with 10% hydrochloric acid as catalyst at room temperature. The obtained products (8)(9)(10)(11)(12) are yellow solids melting at about 200 C (see Experimental).…”

“…[6] Some time ago, we focused our attention to several natural arylolefins (eugenol, methyleugenol, safrole, anethole) from vegetable essential oils that could act as good substrates in order to prepare heterocyclic compounds. For example, many poly-functionalized quinolines were synthesized from eugenol with a convenient route; [8,9] 4,5-dimethoxy-2-(3-methylfuroxan-4-yl) phenylamine (Am), which was synthesized from methyleugenol, acted as a key compound for preparation of some series of imines, azo, 1,3-thiazolidin-4-ones and indoles incorporating furoxan moiety. [10,11] Considering above mentions, we have decided to design and synthesize a series of 6,7-dimethoxy-2-methyl-4-substituted quinazolines and to investigate whether the resulting compounds have useful anti-cancer activities.…”