Synthesis and characterization of polysulfanilamide and its copolymers: bioactivity and drug release

Hypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery

“…Physical entrapment of drugs in hydrogels is one of the common approaches used in drug delivery. Another common approach to load drugs is via chemical cross-linking. − Recently, physical entrapment has sparked a great interest because on the one hand, it can avoid chemical or biochemical interferences with cell activity, when compared to chemical cross-linking; on the other hand, it can also minimize structural changes possibly introduced to the loaded drug. , Moreover, drug loading by physical entrapment does not require any chemical or photochemical triggering and as a result, it can usually be done in a simpler and faster manner . These advantages are particularly important in delivering fragile drugs, such as proteins, peptides, and nucleic acids …”

An unexpected tandem cycloaddition reaction of α,β-unsaturated acid chloride with amines: Synthesis of dihydropyrancarboxamide derivatives and biological activity

“…Monoacylated product was obtained insignificant yield and was detected by GC-MS. Similarly, methacryloyl chloride reacted with 2-aminobezthiazole, 1,3,4-thiadiazol-2-amine, anthranilic acid, o-phenylene diamine and 3-methyl- 110.25 (15) It is of value to mention here that the behavior of amines with MAC is different than that with acryloyl chloride (AC), as reported by our group [25][26][27][28]. Thus, acryloyl chloride reacted with amines under similar condition to give the N-acylated product without further cycloaddtion reaction.…”

Novel synthesis of N‐acrylamidociprofloxacin and related polymers: Bioactivity, drug resistance, and drug release

“…[13][14][15] Additionally, it has been observed that high molecular weight acrylic polymers incorporating drugs exhibit significant pharmacological activity. [16][17][18] The acrylic acid advantage as a co-monomer in a polymeric chain sharing an active drug moiety can assist the cleavage of ester-amide linkages via the participation of a neighboring group. [16][17][18][19][20] Furthermore, the introduction of a hydrophobic, polyelectrolytic, or hydrophilic moiety enhances the effects of drugs on microorganisms.…”

“…[16][17][18] The acrylic acid advantage as a co-monomer in a polymeric chain sharing an active drug moiety can assist the cleavage of ester-amide linkages via the participation of a neighboring group. [16][17][18][19][20] Furthermore, the introduction of a hydrophobic, polyelectrolytic, or hydrophilic moiety enhances the effects of drugs on microorganisms. 21 These properties make such systems very useful and provide longer drug delivery times with lower dosages.…”