Synthesis and characterization of polyvinyl alcohol–silk sericin nanofibers containing gelatin-capped silver nanoparticles for antibacterial applications

Gök, Zehra Gün

doi:10.1007/s00289-022-04455-0

Cited by 12 publications

(3 citation statements)

References 47 publications

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“…Sericin‐coated silver nanoparticles could be a potential candidate to inhibit the growth of microorganisms due to the reducing and stabilizing activity of sericin as well as the ability to resorb silver ions through chelation and ion exchange mechanisms which prevent nanoparticles from aggregation due to protein molecular charge adsorption. Antibacterial action of sericin towards some human cells, for disease resistance, might occur due to the presence of both active amino and OH functional groups (Gün Gök, 2022; Wang et al, 2018). Sericin‐conjugated silver nanoparticles can also inhibit the growth of bacteria due to the production of high levels of free radicals and ROS that are responsible to prohibit the growth of cells and respiration (Hamed et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the antimicrobial potential of sericin‐coated silver nanoparticles against human pathogens

Ali

Kazmi

Mughal

et al. 2022

Microscopy Res & Technique

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The antibacterial activity of synthetic antimicrobial agents is well known, but most of them have several side effects and are effective against selective microbes. Recently, major concern for the microbiologists is to investigate for some stable, non-toxic, cheap, and eco-friendly antimicrobial agents with a wide range of bactericidal potential. A cost-effective and environmentally friendly alternate has been proposed in the form of green synthesized nanoparticles. The Present study was designed to fabricate sericin-coated silver nanoparticles (S-AgNPs) using sericin as stabilizer and reductant of silver ions and their antibacterial potential was evaluated at various concentrations and temperatures (8, 40, and 50 C). Antimicrobial activities were assessed by the agar well diffusion method. Antibacterial activity of S-AgNPs was measured at different concentrations (1-6 mg/ml) whereas; antifungal activity was tested at 5-20 mg/ml of S-AgNPs. Nanoparticles were characterized by UV-visible spectrophotometer, Fourier transform infrared spectroscopy, and scanning electron microscopy. These nanoparticles significantly subdued the growth of Clostridium difficile (18.7 ± 0.9 mm), Proteus mirabilis (12.3 ± 0.3 mm) and Bacillus licheniformis (10.7 ± 0.9 mm) and Aspergillus flavus (18.7 ± 2.0 mm), Mucor mycetes (13 .0 ± 1.5 mm), Candida albicans (15.3 ± 0.3 mm) and Aspergillus niger (10.0 ± 0.6 mm). S-AgNPs were stable at all temperatures and the maximum growth inhibition was found at 8 C for all pathogenic strains.We concluded that the S-AgNPs could be a potential candidate to inhibit the growth of bacterial and fungal pathogens at a wide range of environmental conditions like temperature. In various biomedical applications including antimicrobial and wound dressings, S-AgNPs can be used in the future to treat various bacterial and fungal infections.

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Section: Discussionmentioning

confidence: 99%

Analysis of the antimicrobial potential of sericin‐coated silver nanoparticles against human pathogens

Ali

Kazmi

Mughal

et al. 2022

Microscopy Res & Technique

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“…[15] Similar investigations involving nanofiber surfaces crafted from a blend of polyvinyl alcohol and silk sericin protein (PVA:SS) with gelatin-coated silver nanoparticles (G-AgNPs) demonstrated an inhibition in bacterial growth which may enable its applicability in preparation wound dressing material. [16] The conventional method of silk degumming uses soap and alkali for removal of sericin. Various other methods of degumming also uses enzymes, [17] acids, [18] bio surfactants such as saponin isolated from Acacia concinna (Willd.)…”

Section: Introductionmentioning

confidence: 99%

“…Membranes comprising poly(vinyl alcohol)/silk sericin were readily synthesized for effective elimination of negatively charged pollutants like remazol black B (RBB) from liquid solutions [15] . Similar investigations involving nanofiber surfaces crafted from a blend of polyvinyl alcohol and silk sericin protein (PVA:SS) with gelatin‐coated silver nanoparticles (G‐AgNPs) demonstrated an inhibition in bacterial growth which may enable its applicability in preparation wound dressing material [16] …”

Section: Introductionmentioning

confidence: 99%

Efficient Extraction of Sericin Protein from Mulberry and Non‐Mulberry Silk Fibers: Utilizing Aqueous Ionic Liquid Solutions as Green Solvents

Kalita,

Sarma,

Kalita

et al. 2024

ChemistrySelect

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Protein extraction from silk is a unique area of research and the foremost need is the efficient extraction of the silk proteins namely fibroin and sericin from the silk fibres, which is conventionally done using chemicals. In this work, we show that Ionic liquids (ILs) can be employed as a green and alternative method for degumming sericin from both mulberry (B. mori) and non‐mulberry (A. assamensis and P. ricini) silk. Six different ILs with varying tail lengths were studied for their degumming efficiencies. The interaction between silk proteins and IL ions involves a complex ionic disruption of hydrogen bonds, non‐polar interactions, and electrostatic effects. We have found that 1‐Butyl‐3‐methylimidazolium chloride (BMIM.Cl), 1‐ethyl‐3‐methylimidazolium tetrafluoroborate (EMIM.BF4) and Tetraethylammonium bromide (TEAB) bring in higher weight loss % in silk fibres compared to other ILs, indicating that it can be used in better sericin removal without significant damage to the silk fibre. TEAB emerged as a potential candidate for sericin extraction due to its promotion of protein destabilization. Additionally, no drastic changes in the structure of the extracted silk protein sericin were observed, as evident from the FTIR spectra and SEM images. This work highlights for the first time, the use of ILs for extraction of non‐mulberry silk sericin and also proves that ILs can be a potential green solvent for sericin extraction.

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Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity and permeability to air and water, effective barrier properties against external pathogens, and excellent resemblance to the extracellular matrix for wound healing and skin regeneration. This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. The review begins with an overview of the wound healing process and electrospinning methods. It then explores the advantages and disadvantages of different synthetic and natural polymers used in the preparation of electrospinning wound dressings. The natural polymers discussed in this review include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, and sodium alginate. Additionally, the review delves into commonly used synthetic polymers like polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane for wound dressing applications. Furthermore, the review examines the blending of natural and synthetic polymers to create high‐performance wound dressings. It also explores the incorporation of functional additives, such as antimicrobial agents, growth factors, and natural extracts, into electrospinning nanofibers to expedite wound healing and tissue repair. In conclusion, electrospinning is an emerging technology that provides unique opportunities for designing more effective wound dressings and care products.

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Synthesis and characterization of polyvinyl alcohol–silk sericin nanofibers containing gelatin-capped silver nanoparticles for antibacterial applications

Cited by 12 publications

References 47 publications

Analysis of the antimicrobial potential of sericin‐coated silver nanoparticles against human pathogens

Analysis of the antimicrobial potential of sericin‐coated silver nanoparticles against human pathogens

Efficient Extraction of Sericin Protein from Mulberry and Non‐Mulberry Silk Fibers: Utilizing Aqueous Ionic Liquid Solutions as Green Solvents

Advances in wound dressing based on electrospinning nanofibers

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