Synthesis and characterization of Pt(II) complexes with amine and carboxylato ligands. Crystal structure of (1,1-cyclobutanedicarboxylato)di(ethylamine)platinum(II)·H2O

A novel platinum complex of the histone deacetylase inhibitor belinostat: Rational design, development and in vitro cytotoxicity

“…[5,23] . This observation strongly suggests that the cis-diammine Pt(II) moiety coordinates to mal-p-Bel via the dicarboxylate groups [25] and through the two deprotonated hydroxy groups to form a very stable six-membered chelate.…”

The Relevance of Polar Surface Area (PSA) in Rationalizing Biological Properties of Severalcis‐Diamminemalonatoplatinum(II) Derivatives

“…[27] The method consists of treating 4 ] in solution; the latter complex reacts with amines to produce the cis-[Pt-…”

Synthesis, Characterization and Cytotoxicity of Diam(m)‐ineplatinum(II) Complexes Containing β‐phenylisosuccinate Ligand

“…Moreover, b-phenylisosuccinate is an important ingredient from natural plants and it is hardly toxic. A few of the diam(m)ineplatinum complexes containing b-phenylisosuccinate ligand have been synthesized and reported in the literature, but there is no data about their cytotoxicity [11,12]. We report the synthesis and cytotoxicity of the platinum(II) complexes with b-phenylisosuccinate and one of the complexes shows significant in-vitro cytotoxicity against the tested cell lines, much more activity than cisplatin and carboplatin.…”