Synthesis and characterization of Pt complexes containing dichloroacetate (DCA), designed for dual anticancer action

Ferretti, Valeria; Bergamini, Paola; Marvelli, Lorenza; Hushcha, Yekatsiaryna; Gemmo, Chiara; Gambari, Roberto; Lampronti, Ilaria

doi:10.1016/j.ica.2017.04.048

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…[27] Other attractive complexes are the neutral [Ru(N-N)-(PTA) 2 Cl 2 ] {N-N = bpy (10), N-N = phen (11)}, monocationic [Ru(N-N)(PTA) 3 Cl]Cl {N-N = bpy (12), N-N = phen(13)} and, di-Scheme 1. [29][30][31] It was showed that the co-ligands bonded to the {Pt(2,2-bpy)} + moiety have a large influence on the reaction kinetics of the complexes with biomolecules such as amino acids, proteins, and DNA. Adapted from ref.…”

Section: Complexes With Pta and Derivatives Different To Dmoptamentioning

confidence: 99%

“…Recently new Pt‐PTA complexes ( 16 , 17 , Scheme ) with improved antiproliferative properties have been published . It was showed that the co‐ligands bonded to the {Pt(2,2‐bpy)} + moiety have a large influence on the reaction kinetics of the complexes with biomolecules such as amino acids, proteins, and DNA .…”

Section: Complexes With Pta and Derivatives Different To Dmoptamentioning

confidence: 99%

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New Findings in Metal Complexes with Antiproliferative Activity Containing 1,3,5‐Triaza‐7‐phosphaadamantane (PTA) and Derivative Ligands

et al. 2019

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This minireview summarizes some of the most significant findings published in the last years on metal complexes containing PTA and PTA derivatives ligands such as dmoPTA, with antiproliferative activity [PTA = 1,3,5-triaza-7-phospha- [a] 1529 Pablo Lorenzo-Luis completes his B.Sc. Degree at La Laguna-University-ULL and he received his Ph.D. from the same University (July 1998) under the supervision of Full Professor P. Gili. Soon after, he moved to ISSECC-CNR-Florence, Italy with Dr. S. Midollini where he worked in the Metal Phosphonate Chemistry. He spent two months (2001) in the same place (now ICCOM-CNR) with Dr. M. Peruzzini conducting basic research on Organometallic Chemistry and Catalysis. He is currently as Lecturer at that University (ULL-Inorganic Chemistry Section from 2004-) and co-author of more than a sixty scientific papers in peer-reviewed journals and he has been supervisor of several Ph.D. students on ruthenium complexes with "Doctor Europaeus Mention". Eur. J. Inorg. Chem. 2019, 1529-1538 www.eurjic.org

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Section: Complexes With Pta and Derivatives Different To Dmoptamentioning

confidence: 99%

Section: Complexes With Pta and Derivatives Different To Dmoptamentioning

confidence: 99%

New Findings in Metal Complexes with Antiproliferative Activity Containing 1,3,5‐Triaza‐7‐phosphaadamantane (PTA) and Derivative Ligands

et al. 2019

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“…were investigated against both Pt sensitive A2780 and Pt resistant SKOV-3 human cancer cell lines. [90] The amine complexes 42-43…”

Section: Savino Et Al Synthesized and Characterized Two Novel Platinummentioning

confidence: 99%

“…were slightly more active against Pt sensitive A2780 cells than the antiproliferative property on both cell lines. [90] A number of Pt(II) complexes have been reported for their anticancer activities where DCA was not directly coordinated with the Pt(II); rather it was a part of the ligands of the complexes. For example, a number of mixed-NH 3 /amine platinum(II) complexes of 3-dichloroacetoxylcyclobutane-1, 1-dicarboxylate (48a-48c, 49-51;…”

Section: Savino Et Al Synthesized and Characterized Two Novel Platinummentioning

confidence: 99%

“…The antiproliferative activity of complexes 43 – 47 (Figure 19) were investigated against both Pt sensitive A2780 and Pt resistant SKOV‐3 human cancer cell lines. [ 90 ] The amine complexes 42 – 43 were slightly more active against Pt sensitive A2780 cells than the complexes 45 – 47 . However, the amine complexes 42 – 43 were noticeably less cytotoxic toward Pt resistant SKOV‐3, which resembles cisplatin behavior, while 45 – 47 displayed the same anticancer activity as A2780.…”

Section: Derivatives Of Dichloroacetic Acidmentioning

confidence: 99%

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Cytotoxic derivatives of dichloroacetic acid and some metal complexes

Hossain

Roth

Dimmock

et al. 2022

Archiv der Pharmazie

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This study outlines a number of studies of dichloroacetic acid (DCA) and some of its derivatives. Although DCA has low cytotoxic potencies, various structural modifications are described which result in potent cytotoxins. In particular, hybrid molecules created from DCA and other bioactive molecules whose modes of action differ from DCA are particularly promising as candidate anticancer agents. Considerable emphasis in this review is placed on various series of compounds that incorporate both platinum and DCA into their structures. In addition, the importance of the formulation of some of the bioactive compounds described herein is revealed.

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Platinum(IV) and platinum(II) anticancer complexes with biologically active releasable ligands

Štarha,

Křikavová

2024

Coordination Chemistry Reviews

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Synthesis and characterization of Pt complexes containing dichloroacetate (DCA), designed for dual anticancer action

Cited by 8 publications

References 37 publications

New Findings in Metal Complexes with Antiproliferative Activity Containing 1,3,5‐Triaza‐7‐phosphaadamantane (PTA) and Derivative Ligands

New Findings in Metal Complexes with Antiproliferative Activity Containing 1,3,5‐Triaza‐7‐phosphaadamantane (PTA) and Derivative Ligands

Cytotoxic derivatives of dichloroacetic acid and some metal complexes

Platinum(IV) and platinum(II) anticancer complexes with biologically active releasable ligands

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