Synthesis and Characterization of Radiopaque Iodine-containing Degradable PVA Hydrogels

Mawad, Damia; Poole-Warren, Laura A.; Martens, Penny J.; Koole, Léo H.; Slots, Tristan; Hooy-Corstjens, Catharina S. J. van

doi:10.1021/bm700754m

Cited by 48 publications

(32 citation statements)

References 27 publications

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“…There are numerous recent examples of imageable beads that are visualized by X-ray (e.g. fluoroscopy and CT) 12 - 16 , magnetic resonance imaging 17 - 21 , or both 22 , 23 . However, these imageable beads have not obtained widespread clinical adoption.…”

Section: Introductionmentioning

confidence: 99%

A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study

Durán¹,

Sharma

Dreher

et al. 2016

Theranostics

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Purpose: Embolotherapy using microshperes is currently performed with soluble contrast to aid in visualization. However, administered payload visibility dimishes soon after delivery due to soluble contrast washout, leaving the radiolucent bead's location unknown. The objective of our study was to characterize inherently radiopaque beads (RO Beads) in terms of physicomechanical properties, deliverability and imaging visibility in a rabbit VX2 liver tumor model.Materials and Methods: RO Beads, which are based on LC Bead® platform, were compared to LC Bead. Bead size (light microscopy), equilibrium water content (EWC), density, X-ray attenuation and iodine distribution (micro-CT), suspension (settling times), deliverability and in vitro penetration were investigated. Fifteen rabbits were embolized with either LC Bead or RO Beads + soluble contrast (iodixanol-320), or RO Beads+dextrose. Appearance was evaluated with fluoroscopy, X-ray single shot, cone-beam CT (CBCT).Results: Both bead types had a similar size distribution. RO Beads had lower EWC (60-72%) and higher density (1.21-1.36 g/cc) with a homogeneous iodine distribution within the bead's interior. RO Beads suspension time was shorter than LC Bead, with durable suspension (>5 min) in 100% iodixanol. RO Beads ≤300 µm were deliverable through a 2.3-Fr microcatheter. Both bead types showed similar penetration. Soluble contrast could identify target and non-target embolization on fluoroscopy during administration. However, the imaging appearance vanished quickly for LC Bead as contrast washed-out. RO Beads+contrast significantly increased visibility on X-ray single shot compared to LC Bead+contrast in target and non-target arteries (P=0.0043). Similarly, RO beads demonstrated better visibility on CBCT in target arteries (P=0.0238) with a trend in non-target arteries (P=0.0519). RO Beads+dextrose were not sufficiently visible to monitor embolization using fluoroscopy.Conclusion: RO Beads provide better conspicuity to determine target and non-target embolization compared to LC Bead which may improve intra-procedural monitoring and post-procedural evaluation of transarterial embolization.

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Section: Introductionmentioning

confidence: 99%

A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study

Durán¹,

Sharma

Dreher

et al. 2016

Theranostics

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“…Most applications of this nature require nondestructive, nontoxic, diagnostic evaluation procedures. Extensive research in this area has concentrated on idio-polymer compounds (42)(43)(44)(45): Some materials have already been commercialized, and others are still in developmental stage. Some of these monomers based on iodophenyl derivative contain three covalent-bonded iodine atoms, having a combined atomic weight of 381, which is almost 1.8 times more than bismuth (atomic weight 209).…”

Section: Applicationsmentioning

confidence: 99%

Radiopaque Polymers

Cabasso¹

2011

Encyclopedia of Polymer Science and Technology

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Radiopaque polymers have been primarily developed for the service of radiographic nondestructive evaluation by x‐rays absorption. The x‐ray adsorption depends on the fourth power of the atomic number, and consequently elements with high atomic number are associated with effective x‐ray absorption of a material. Materials that are composed of solely of light elements as most polymers are essentially x‐ray transparent. The synthesis of a radiopaque polymer is accomplished by either dispersing the radiopacifying agent into the polymer resin or permanently anchoring the additive to the polymer matrix. So far, only elements in the sixth period (or higher) of the periodical table, except iodine, have been found commonly useful as radiopaque compounds. Iodine, barium, lead, bismuth, and to a lesser degree other organometallic compounds, which can be incorporated into a variety of polymers, have been presently in use in the medical and other fields. Toxicity and uncontrolled degradation and release of the radiopacifier from the polymer matrix are the important factors in the selection of these materials. The preparation, systems relation and measurements, and a wide variety of radiopaque polymers are discussed.

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“…Although there is variance in the structure and delivery method of contrast agents, almost all iodine‐based contrast materials described in the literature utilize aromatic ring‐bound iodine . Many of these precursors are expensive and toxic; however, they presumably increase the stability of the bound iodine.…”

Section: Introductionmentioning

confidence: 99%

Iodinated polyesters as a versatile platform for radiopaque biomaterials

Houston

Brosnan

Burk

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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The design of polymeric biomaterials with long‐lasting X‐ray contrast could advance safe and effective implants and contrast agents. Herein, a new set of wholly aliphatic, iodinated polyesters are synthesized and evaluated as high‐contrast biomaterials and nanoparticle contrast agents for general computed tomography imaging. A single iodinated monomer is used to synthesize a variety of aliphatic polyesters with tunable thermal and mechanical properties. These iodinated polyesters are end‐functionalized with a photocurable methacrylate group, which allows easy processability. The resulting materials exhibit no cytotoxicity and are radiopaque, containing over 40% iodine by weight after processing. The polymers can be formulated into lipid–polymer hybrid nanoparticles using a modified nanoprecipitation method. Initial studies indicate that these nanoparticles show good continual contrast over 60 minutes with no uptake into the kidneys. The work presented here illustrates a novel platform for iodinated polyesters that exhibit high radiopacity and processability, low cost, and no cytotoxicity. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2171–2177

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Synthesis and Characterization of Radiopaque Iodine-containing Degradable PVA Hydrogels

Cited by 48 publications

References 27 publications

A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study

A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study

Radiopaque Polymers

Iodinated polyesters as a versatile platform for radiopaque biomaterials

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