Synthesis and Characterization of Schiff Base Complexes of o-Vanillin and Anthranilic Acid and Their Biological Evaluation

Abstract

Complexes of Schiff base derived from o-vanillin (2-hydroxy-3-methoxybenzaldehyde) and anthranilic acid (2-aminobenzoic acid) has been used for complexation with Mn(II), Fe(II) and Co(II). The complexes have been formulated as [ML2X2] where X = pyridine or αpicoline on the basic of their microanalysis. Infrared spectral study has been made to confirm the coordination sites of the Schiff base. The magnetic susceptibility and electronic spectral study leads to tetragonally distorted octahedral symmetry (T4h) of complexes. Their biological evaluation with different strains of bacteria suggest that the complexes are more active than the ligand against both Gram-positive and Gram-negative bacteria.

Spectroscopic Elucidation of Some Complexes of Vanillin Semicarbazone

“…In complexes this band undergoes red shift and appears at 1590-1610 cm -1 . It confirms the coordination of N of azomethine moiety of the ligand [28][29][30][31] . A tacit support for the above propositions is brought out more clearly from the far FTIR spectra of the complexes which display new weak bands appearing at 495-500 cm -1 and 420-725 cm -1 due to n M-N & n M-O stretching vibration respectively [32][33] .…”

Studies on some Anthranilic acid based mixed ligand Metal(II) complexes: Synthesis, characterization, in-vitro biological evaluation, ADMET profiling, DFT and molecular docking

“…14 On complexation this value is shifted to the spectral region 1625 − 1617 and 1415 − 1400 cm − 1 .This occurs because of asymmetric as well as symmetric stretching vibrations of -COO − group resulting from deprotonation. 15 The difference between the symmetric and asymmetric stretching should be approximately 200 cm − 1 . The bands noticed in the 3441 − 3406 cm − 1 region show evidence for the existence of coordinated H 2 O molecules in the metal complexes.…”