Synthesis and characterization of silver nanoparticles developed using a novel lipopeptide(s) biosurfactant and evaluating its antimicrobial and cytotoxic efficacy.

Chauhan, Vivek; Dhiman, Vivek Kumar; Mahajan, Gaytri; Pandey, Akash; Kanwar, Shamsher S.

doi:10.1016/j.procbio.2022.11.002

Cited by 20 publications

(6 citation statements)

References 52 publications

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“…On the other hand, the internalisation into the metal nanoparticles contributes to a further increase in the antimicrobial activity of BSs, enhancing their biodistribution and limiting unfavourable interactions with unspecific targets. For example, in Chauhan et al (2022), lipopeptide OXDC12 silver nanoparticles possessed remarkable antibacterial activities against Gram-negative Salmonella typhimurium , Klebsiella pneumnoniae and E. coli strains, with MIC values lower than the lipopeptide mixture alone [ 142 ]. In 2020, Shikha and collaborators developed gold nanoparticle (AuNps) green synthesis using sophorolipids (SLs) as a non-toxic reducing and stabilising agent; they demonstrated that the obtained AuNPs-SL had higher efficacy in inhibiting the metabolic activity of viable Gram-negative Vibrio cholerae and E. coli cells as well as in killing V. cholerae in its non-multiplying stage, compared to AuNPs or SL alone.…”

Section: Utilizing Biosurfactants As Adjuvants In Medicine: Drug Deli...mentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal and antiviral effects, and antioxidant, anticancer and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formations in clinical, hygiene and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro- and nanoemulsions and hydrogels, improving drug solubility, stability and bioavailability, and enabling a targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound-healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analysing the most recent literature, this review aims to update the present understanding, highlight emerging trends, and identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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Section: Utilizing Biosurfactants As Adjuvants In Medicine: Drug Deli...mentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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“…The potential of iturin-based lipopeptides as drug-delivery vehicles has been the subject of investigation (Figure 2). The attractiveness of these substances lies in their amphiphilic properties and their capacity to spontaneously form micelles or vesicles, which enables them to encapsulate and transport hydrophobic medication [118]. The utilization of iturin in drug delivery systems can be altered by including targeting ligands or antibodies, enabling precise and directed administration to intended locations [119].…”

Section: Drug-delivery Systemsmentioning

confidence: 99%

Iturin: A Promising Cyclic Lipopeptide with Diverse Applications

Yaraguppi,

Bagewadi,

Patil

et al. 2023

Biomolecules

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This comprehensive review examines iturin, a cyclic lipopeptide originating from Bacillus subtilis and related bacteria. These compounds are structurally diverse and possess potent inhibitory effects against plant disease-causing bacteria and fungi. Notably, Iturin A exhibits strong antifungal properties and low toxicity, making it valuable for bio-pesticides and mycosis treatment. Emerging research reveals additional capabilities, including anticancer and hemolytic features. Iturin finds applications across industries. In food, iturin as a biosurfactant serves beyond surface tension reduction, enhancing emulsions and texture. Biosurfactants are significant in soil remediation, agriculture, wound healing, and sustainability. They also show promise in Microbial Enhanced Oil Recovery (MEOR) in the petroleum industry. The pharmaceutical and cosmetic industries recognize iturin’s diverse properties, such as antibacterial, antifungal, antiviral, anticancer, and anti-obesity effects. Cosmetic applications span emulsification, anti-wrinkle, and antibacterial use. Understanding iturin’s structure, synthesis, and applications gains importance as biosurfactant and lipopeptide research advances. This review focuses on emphasizing iturin’s structural characteristics, production methods, biological effects, and applications across industries. It probes iturin’s antibacterial, antifungal potential, antiviral efficacy, and cancer treatment capabilities. It explores diverse applications in food, petroleum, pharmaceuticals, and cosmetics, considering recent developments, challenges, and prospects.

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“…Another reason for observing such a result could be related to the seeding density and the culture materials used. Other studies have been conducted using widely varying methods and seeding densities (from 10 5 CFU/mL [52] to 10 6 CFU/mL [53], to 10 9 CFU/mL [54]). No significant statistical differences between nanoparticle types were observed.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Their attractive antimicrobial properties arise from metal ion release (bactericidal), oxidative stress, and non-oxidative mechanisms (Table 1) [43][44][45][46][47][48][49]. Silver nanoparticles (AgNPs) have long been considered for their antibacterial capacity, although their cytotoxicity has significantly hindered their progress toward clinical application [50][51][52][53][54][55]. Meanwhile, titanium dioxide nanoparticles (TiO 2 NPs) have shown antibacterial efficacy while demonstrating better cytocompatibility [56][57][58][59][60] and even promoting bone formation owing their osteoconductive properties [57,[61][62][63][64].…”

Section: Introductionmentioning

confidence: 99%

Titanium-Dioxide-Nanoparticle-Embedded Polyelectrolyte Multilayer as an Osteoconductive and Antimicrobial Surface Coating

Rothpan,

Chandra Teja Dadi,

McKay

et al. 2023

Materials

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Bioactive surface coatings have retained the attention of researchers and physicians due to their versatility and range of applications in orthopedics, particularly in infection prevention. Antibacterial metal nanoparticles (mNPs) are a promising therapeutic, with vast application opportunities on orthopedic implants. The current research aimed to construct a polyelectrolyte multilayer on a highly porous titanium implant using alternating thin film coatings of chitosan and alginate via the layer-by-layer (LbL) self-assembly technique, along with the incorporation of silver nanoparticles (AgNPs) or titanium dioxide nanoparticles (TiO2NPs), for antibacterial and osteoconductive activity. These mNPs were characterized for their physicochemical properties using quartz crystal microgravimetry with a dissipation system, nanoparticle tracking analysis, scanning electron microscopy, and atomic force microscopy. Their cytotoxicity and osteogenic differentiation capabilities were assessed using AlamarBlue and alkaline phosphatase (ALP) activity assays, respectively. The antibiofilm efficacy of the mNPs was tested against Staphylococcus aureus. The LbL polyelectrolyte coating was successfully applied to the porous titanium substrate. A dose-dependent relationship between nanoparticle concentration and ALP as well as antibacterial effects was observed. TiO2NP samples were also less cytotoxic than their AgNP counterparts, although similarly antimicrobial. Together, these data serve as a proof-of-concept for a novel coating approach for orthopedic implants with antimicrobial and osteoconductive properties.

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Synthesis and characterization of silver nanoparticles developed using a novel lipopeptide(s) biosurfactant and evaluating its antimicrobial and cytotoxic efficacy.

Cited by 20 publications

References 52 publications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Iturin: A Promising Cyclic Lipopeptide with Diverse Applications

Titanium-Dioxide-Nanoparticle-Embedded Polyelectrolyte Multilayer as an Osteoconductive and Antimicrobial Surface Coating

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