Synthesis and characterization of simple and binary drug delivery systems for sustainable release of ciprofloxacin

Quintero-Ortega, Iraís A.; Romero-Argote, Francisco J.; Negrete, Jorge Alfonso Tavares; Elizalde-Peña, Eduardo A.; García, Zaira Y. Carvajal; Pérez-Pérez, Cristina; Sánchez, Isaac C.; Luna‐Bárcenas, Gabriel; Torre, Argelia Rosillo-de la

doi:10.1080/00914037.2018.1534111

Cited by 5 publications

(5 citation statements)

References 60 publications

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“…The incorporation of PEG400 enhanced the burst effect by 10%, arguably because zein chains are less entangled and allow faster diffusion of the NA through the polymeric matrix. The hydrophilicity of PEG400 may also play an important role in the diffusion of NA, as shown elsewhere for different pharmaceutics and drug-delivery materials. , At 48 h, a significantly higher NA load was released from the ZP tablet formulations (93.84 ± 2.98%) than from the Z formulations (65.49 ± 1.73%).…”

Section: Resultsmentioning

confidence: 56%

“…The hydrophilicity of PEG400 may also play an important role in the diffusion of NA, as shown elsewhere for different pharmaceutics and drug-delivery materials. 97,98 At 48 h, a significantly higher NA load was released from the ZP tablet formulations (93.84 ± 2.98%) than from the Z formulations (65.49 ± 1.73%).…”

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

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Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Negrete

Aceves-Colin

Rivera-Flores

et al. 2021

ACS Biomater. Sci. Eng.

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The use of three-dimensional (3D) printing for biomedical applications has expanded exponentially in recent years. However, the current portfolio of 3D printable inks is still limited. For instance, only few protein matrices have been explored as printing/bioprinting materials. Here, we introduce the use of zein, the primary constitutive protein in maize seeds, as a 3D printable material. Zein-based inks were prepared by dissolving commercial zein powder in ethanol with or without polyethylene glycol (PEG400) as a plasticizer. The rheological characteristics of our materials, studied during 21 days of aging/maturation, showed an increase in the apparent viscosity as a function of time in all formulations. The addition of PEG400 decreased the apparent viscosity. Inks with and without PEG400 and at different maturation times were tested for printability in a BioX bioprinter. We optimized the 3D printing parameters for each ink formulation in terms of extrusion pressure and linear printing velocity. Higher fidelity structures were obtained with inks that had maturation times of 10 to 14 days. We present different proof-of-concept experiments to demonstrate the versatility of the engineered zein inks for diverse biomedical applications. These include printing of complex and/or free-standing 3D structures, tablets for controlled drug release, and scaffolds for cell culture.

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Section: Resultsmentioning

confidence: 56%

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Negrete

Aceves-Colin

Rivera-Flores

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…The incorporation of PEG400 enhanced the burst effect by 10%, arguably because zein chains are less entangled and allow faster diffusion of the NA through the polymeric matrix. The hydrophilicity of PEG400 may also play an important role in the diffusion of NA, as shown elsewhere for different pharmaceutics and drug delivery materials [60,61]. At 48 h, a significantly higher NA load was released from the ZP tablet formulations (93.84 ± 2.98%) than from the Z formulations (65.49 ± 1.73%).…”

Section: Biomedical Applications: Drug Releasementioning

confidence: 53%

Biofabrication using maize protein: 3D printing using zein formulations

Negrete

Aceves-Colin

Rivera-Flores

et al. 2020

Preprint

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The use of three-dimensional (3D) printing for biomedical applications has expanded exponentially in recent years. However, the current portfolio of 3D printable inks is still limited. For instance, only a few protein matrices have been explored as printing/bioprinting materials. Here, we introduce the use of zein, the primary constitutive protein in maize seeds, as a 3D-printable material. Zein-based inks were prepared by dissolving commercial zein powder in ethanol with or without polyethylene glycol (PEG400) as a plasticizer. The rheological characteristics of our materials, studied during 21 days of aging/maturation, showed an increase in the apparent viscosity as a function of time in all formulations. The addition of PEG 400 decreased the apparent viscosity. Inks with and without PEG400 and at different maturation times were tested for printability in a BioX bioprinter. We optimized the 3D printing parameters for each ink formulation in terms of extrusion pressure and linear printing velocity. Higher fidelity structures were obtained with inks that had maturation times of 10 to 14 days. We present different proof-of-concept experiments to demonstrate the versatility of the engineered zein inks for diverse biomedical applications. These include printing of complex and/or free-standing 3D structures, materials for controlled drug release, and scaffolds for cell culture.

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“…In this context, hydrogels based on natural polymers have been extensively studied for applications in biomedicine due to their intrinsic characteristics of biocompatibility, biodegradability, and similarities to the extracellular matrix [45,[77][78][79]. The physicochemical characteristics of biopolymeric hydrogels used in drug delivery systems, namely molecular weight, solubility, morphology, hydrophilicity, hydrophobicity, loading and release efficiency of the drug, surface energy, gelation process, etc., have been investigated [80][81][82]. Due to their natural abundance, biocompatibility, and physicochemical properties, hydrogels based on polysaccharides, specifically Alg and CS, are potentially used as drug delivery systems.…”

Section: Advantages Of Polyhy In Controlled Drug Distributionmentioning

confidence: 99%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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In recent years, polymeric hydrogels (PolyHy) have been extensively explored for their applications in biomedicine as biosensors, in tissue engineering, diagnostic processes, and drug release. The physical and chemical properties of PolyHy indicate their potential use in regulating drug delivery. Calcineurin inhibitors, particularly cyclosporine (CsA) and tacrolimus (TAC), are two important immunosuppressor drugs prescribed upon solid organ transplants. Although these drugs have been used since the 1970s to significantly increase the survival of transplanted organs, there are concerns regarding their undesirable side effects, primarily due to their highly variable concentrations. In fact, calcineurin inhibitors lead to acute and chronic toxicities that primarily cause adverse effects such as hypertension and nephrotoxicity. It is suggested from the evidence that the encapsulation of calcineurin inhibitors into PolyHy based on polysaccharides, specifically alginate (Alg), offers effective drug delivery with a stable immunosuppressive response at the in vitro and in vivo levels. This not only may reduce the adverse effects but also would improve the adherence of the patients by the effective preservation of drug concentrations in the therapeutic ranges.

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Synthesis and characterization of simple and binary drug delivery systems for sustainable release of ciprofloxacin

Cited by 5 publications

References 60 publications

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Biofabrication using maize protein: 3D printing using zein formulations

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

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