Synthesis and characterization of small-sized gold nanoparticles coated by bovine serum albumin (BSA) for cancer photothermal therapy

Al-Jawad, Selma M. H.; Taha, Ali A.; Al-Halbosiy, Mohammad M. F.; AL-Barram, Lamyaa F. A.

doi:10.1016/j.pdpdt.2017.12.004

Cited by 50 publications

(25 citation statements)

References 34 publications

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“…The protein used in the experiment was Bovine Serum Albumin (BSA). BSA is a rigid, neutral, stable, moderately non-reactive protein [2,3]. It adsorbs to any type of surface and has high stability [4].…”

Section: Methodsmentioning

confidence: 99%

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Influence of the Geometry on the LTCC Integrated Electrochemical Cells Performance

2018

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Miniaturized and integrated analytical devices, including chemical sensors, are at the forefront of modern analytical chemistry. The construction of novel analytical tools takes advantage of contemporary micro- and nanotechnologies, as well as materials science and technology. The goal of this study was investigate electron transfer resistance in model solution and protein adsorption using integrated electrochemical cell with different geometry.

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Section: Methodsmentioning

confidence: 99%

“…The sensors were made in such way that they can be easily inserted directly in the micro USB connector and placed in the 8-channel measurement head vertically in the wells of a 24-well titrate plate. Impedance analyzer IMP-STM32 [3] was used in the measurements. Range of frequency was 10 mHz to 100 kHz.…”

Section: Methodsmentioning

confidence: 99%

Influence of the Geometry on the LTCC Integrated Electrochemical Cells Performance

2018

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“…Furthermore, Akrami, Khoobi, Khalilvand-Sedagheh, Haririan, Bahador, Faramarzi, Rezaei, Javar, Salehi and Ardestani [163] developed a magnetic iron oxide NPs with an anticancer drug as curcumin coated with HP corona protein that reduced the growth and proliferation of breast cancer cells compared to free NPs. Since the NPs less than 5 nm exhibit the lowest toxicity due to fast filtration of the kidneys, AL-Jawad, Taha, Al-Halbosiy and AL-Barram [164] produced small AuNPs (<5 nm) coated with BSA to increase stability (with increasing particle size) which in addition to increasing photothermal therapy by laser irradiation in cancer cell lines, showed the least toxicity (up to 70%). Similarly, Hai, Piraux, Mazario, Volatron, Ha-Duong, Decorse, Lomas, Verbeke, Ammar and Wilhelm [165] exhibited that the maghemite NPs coated with HSA corona protein eliminated cancer cell lines by photothermal therapy with very low toxicity.…”

Section: The Impact Of Nps-protein Corona On Cancer Therapymentioning

confidence: 99%

A health concern regarding the protein corona, aggregation and disaggregation

Falahati

Attar²,

Sharifi

et al. 2019

Biochimica et Biophysica Acta (BBA) - General Subjects

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A B S T R A C T Nanoparticle (NP)-protein complexes exhibit the "correct identity" of NP in biological media. Therefore, protein-NP interactions should be closely explored to understand and modulate the nature of NPs in medical implementations. This review focuses mainly on the physicochemical parameters such as dimension, surface chemistry, morphology of NPs, and influence of pH on the formation of protein corona and conformational changes of adsorbed proteins by different kinds of techniques. Also, the impact of protein corona on the colloidal stability of NPs is discussed. Uncontrolled protein attachment on NPs may bring unwanted impacts such as protein denaturation and aggregation. In contrast, controlled protein adsorption by optimal concentration, size, pH, and surface modification of NPs may result in potential implementation of NPs as therapeutic agents especially for disaggregation of amyloid fibrils. Also, the effect of NPs-protein corona on reducing the cytotoxicity and clinical implications such as drug delivery, cancer therapy, imaging and diagnosis will be discussed. Validated correlative physicochemical parameters for NP-protein corona formation frequently derived from protein corona fingerprints of NPs which are more valid than the parameters obtained only on the base of NP features. This review may provide useful information regarding the potency as well as the adverse effects of NPs to predict their behavior in vivo.

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“…-BSA NPs. The mPEG-Rg3-BSA NPs were prepared using a desolvation technique [22][23][24]. As shown in Figure 2(b), BSA (2 mL, 10 mg/mL) was first dissolved in ultrapure water; then, NaOH solution (30 μL, 0.02 mg/mL) was slowly added to the BSA solution.…”

Section: Preparation Of Mpeg-rg3mentioning

confidence: 99%

PEGylation of Ginsenoside Rg3-Entrapped Bovine Serum Albumin Nanoparticles: Preparation, Characterization, and In Vitro Biological Studies

Zhang

Hui

et al. 2019

Journal of Nanomaterials

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Ginsenoside Rg3 (Rg3) is one of three triterpene saponins from red ginseng. It has important structural functions and pharmacological properties. However, due to its poor solubility, low bioavailability, and short half-life in blood circulation, its clinical application was unsuccessful for the treatment of a variety of cancers. In order to overcome this limitation, this study prepared mPEGylation-Rg3 bovine serum albumin nanoparticles (mPEG-Rg3-BSA NPs). The characteristics of the NPs, such as drug entrapment efficiency, drug loading efficiency, surface morphology, thermal stability, and cytotoxicity in vitro, were investigated. The results showed that the appropriate particle size of the obtained NPs was 149.5 nm, the water solubility and stability were better than free Rg3, and the drug entrapment efficiency and drug loading efficiency were 76.56% and 17.65%, respectively. Moreover, the cytotoxicity assays of the mPEG-Rg3-BSA NPs and free Rg3 revealed that the mPEG-Rg3-BSA NPs have greater anticancer effects in HepG2 cells and A549 cells. However, the cytotoxic effect of free Rg3 was higher than the mPEG-Rg3-BSA NPs in L929 cells. The results indicated that using the mPEGylation method and selecting BSA as a carrier to form the nanodrug carrier system were effective for improving the properties of Rg3.

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Synthesis and characterization of small-sized gold nanoparticles coated by bovine serum albumin (BSA) for cancer photothermal therapy

Cited by 50 publications

References 34 publications

Influence of the Geometry on the LTCC Integrated Electrochemical Cells Performance

Influence of the Geometry on the LTCC Integrated Electrochemical Cells Performance

A health concern regarding the protein corona, aggregation and disaggregation

PEGylation of Ginsenoside Rg3-Entrapped Bovine Serum Albumin Nanoparticles: Preparation, Characterization, and In Vitro Biological Studies

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