Synthesis and characterization of some new 4,4′-(1,4-phenylene)dipyrimidine and 6,6′-(1,4-phenylene)-di(pyridin-2(1H)-one) derivatives

One‐pot three‐component reaction; synthesis of new symmetrically bridge 4,4′‐(1,4‐phenylene)di‐pyrimidines under solvent free conditions

“…We also proved and confirmed the pathway of the reaction through a two-component condensation of bischalcones 4a-c (which were formed by the reaction of terephthalaldehyde (1) with heterocyclic ketones 2a-c according to published literature [47,53,54]) with Sbenzylthiouronium chloride (3a) using sodium hydroxide as a base, under Solvent-free conditions at 70 C, and the reaction performed smoothly in a short time and the corresponding compounds 6a-c could be obtained with 85%, 88%, 84% yields, respectively. It is proved that onepot three-component reaction is the preferred method for the synthesis of these compounds (Scheme 1).…”

“…Compounds 4a-c [47,53,54], 8a,b [55,56], and 12 [57] were synthesized using the published procedures. (1) (5 mmol) and Sbenzylthiouronium chloride (3a) (15 mmol) were added to the stirred solution.…”

“…As section of our rising interest in synthesizing bisheterocyclic compounds [43][44][45][46][47][48][49][50][51][52], we desire to characterize herein an efficient procedure for the synthesis of a novel series of 4,4 0 -(1,4-phenylene)di-pyrimidines under solvent-free conditions.…”

Synthesis and In Vitro Anticancer Evaluation of Symmetrically Bridged 1,3‐thiazine Derivatives

“…As part of our growing interest in synthesizing bis ‐heterocyclic compounds of interesting biological activities , we report here the versatile and hitherto unreported synthesis of a series of symmetrically functionalized bis ‐thiazines, in which the two substituted heterocycles were linked together through a flexible bridge of alkyl chains with variable number of methylene moieties and their anticancer activities were evaluated against various cancer cells. The bis ‐aldehydes 1a–c were chosen as ideal candidates for the synthesis of the target bis ‐thiazine scaffolds 3a–c because they can undergo nucleophilic attack upon reaction with the bis ‐nucleophile 2a–c followed by subsequent facial cyclization.…”

Synthesis of polyfunctionally substituted benzo[5,6]chromeno[4,3,2-de][1,6]naphthyridines and 5H-benzo[5,6]chromeno[3,4-c]pyridines

“…[8][9][10][11] Furthermore, chromenes and their fused heterocyclic derivatives have attracted a great deal of interest due to their wide applications in the field of pharmaceuticals. [12][13][14][15][16][17] In view of the above mentioned benefits and in continuation of our previous work in developing syntheses of polyfunctionally substituted heterocyclic compounds with potential biological activity, [18][19][20][21][22][23][24][25][26][27] we report here the utility of the 2-(3-amino-2-cyano-1H-benzo[f]chromen-1-yl)-malononitrile (1) as a building block for the synthesis of benzo [5,6]chromeno [4,3,2-de] [1,6]naphthyridines and benzo [5,6]chromeno [3,4-c]pyridine with the purpose of investigating in the future their possible biological activity.…”