Synthesis and Characterization of some new Schiff base Compounds derived from 4-Amino benzoic acid and study their Biological activity

In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram-positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 µg\ml.

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Synthesis, and Antimicrobial Evaluation of New hydrazone Derivatives of (2,4-dinitrophenyl) hydrazine

Sahib

Hadi

Abdulkadir

2022

RJPT

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Synthesis, Characterization and Antioxidant Activity of some New Antipyrine derived Schiff Bases

Fatima,

Kumar. P,

Priya. R

et al. 2024

AJRC

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Synthesis, characterization of a series of some new antipyrine derived Schiff bases 5(a-f) have been carried out and evaluated for their antioxidant activity. The newly synthesized compounds were characterized by physical and spectral data. The compounds 5(a-f) were measured for physical parameters and enlisted. The completion of the reaction, the progress of the reaction, and the purity of all newly produced compounds were monitored by TLC. Compounds in series 5(a-f) have yields that vary from 70 to 93%. Based on a review of the literature, there were no antipyrine derivatived Schiff bases reported till now, hence they were synthesized and characterized in this work. It was found that these moieties were useful in the field of pharmaceutical chemistry and that they demonstrated a variety of pharmacological actions. In the current work, six synthetic compounds 5(a-f) were prepared, and characterized by FTIR, 1HNMR and Mass spectroscopy studies. Melting points were determined and TLC was used to verify the purity of each compound. In an effort to produce new therapeutic compounds these compounds are tested for antioxidant properties and reported.

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Synthesis and Characterization of some new Schiff base Compounds derived from 4-Amino benzoic acid and study their Biological activity

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Synthesis, and Antimicrobial Evaluation of New hydrazone Derivatives of (2,4-dinitrophenyl) hydrazine

Synthesis, and Antimicrobial Evaluation of New hydrazone Derivatives of (2,4-dinitrophenyl) hydrazine

Synthesis, Characterization and Antioxidant Activity of some New Antipyrine derived Schiff Bases

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