Synthesis and characterization of strontium-substituted hydroxyapatite nanoparticles for bone regeneration

Sintering of magnesium‐strontium doped hydroxyapatite nanocrystals: Towards the production of 3D biomimetic bone scaffolds

“…Substitution of Sr 2+ ions at Ca 2+ sites in HA lattice is well reported (Frasnelli et al, 2017;Lowry et al, 2018;Šupovà, 2015;Terra et al, 2009). Substitution of Sr 2+ ions at Ca 2+ sites in HA lattice is well reported (Frasnelli et al, 2017;Lowry et al, 2018;Šupovà, 2015;Terra et al, 2009).…”

89Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

“…[20][21][22] The weak shoulder at 964 cm −1 and the broadband at 1033 cm −1 with shoulder at 1093 cm −1 correspond to the vibrational modes of stretch ν 1 and ν 3 of the phosphate group (PO 4 3− ), while the shoulder at 474 cm −1 and the strong bands at 566 and 601 cm −1 indicate the presence of the vibrational modes ν 2 and ν 4 of flexion of this same group. According to Frasnelli et al, 12 the deformation of the HA unit cell in the c-axis can lead to a limitation in spatial density of the bonds of the OH − . According to Frasnelli et al, 12 the deformation of the HA unit cell in the c-axis can lead to a limitation in spatial density of the bonds of the OH − .…”

“…[4][5][6] It has been well established that strontium (Sr) has great biochemical similarity with calcium (Ca), favoring the easy introduction of this element into the HA matrix. Thus, nanostructured systems composed of Sr-doped HA nanoparticles have already been proposed as therapeutic systems for bone pathologies such as osteoporosis, due to the osteoinductive capacity of HA and Sr. 11 Frasnelli and collaborators 12 showed that, using SAOS-2 cells, the introduction of Sr 2+ ions into the HA network nanoparticles may lead to the production of a biocompatible material and also promote osteoblastic activity. Thus, nanostructured systems composed of Sr-doped HA nanoparticles have already been proposed as therapeutic systems for bone pathologies such as osteoporosis, due to the osteoinductive capacity of HA and Sr. 11 Frasnelli and collaborators 12 showed that, using SAOS-2 cells, the introduction of Sr 2+ ions into the HA network nanoparticles may lead to the production of a biocompatible material and also promote osteoblastic activity.…”

“…[7][8][9] The theoretical study developed by Reginster et al 10 safety and effectiveness of the treatment of this pathology through the use of Sr ranelate. Thus, nanostructured systems composed of Sr-doped HA nanoparticles have already been proposed as therapeutic systems for bone pathologies such as osteoporosis, due to the osteoinductive capacity of HA and Sr. 11 Frasnelli and collaborators 12 showed that, using SAOS-2 cells, the introduction of Sr 2+ ions into the HA network nanoparticles may lead to the production of a biocompatible material and also promote osteoblastic activity.…”

“…Furthermore, the regeneration of affected areas must be favored by HA-Sr materials considering their osteoinductive capacity. 12 In afford of mentioned above, the aim of this work was to synthesize radiolabeled 89 Sr-doped HA nanorods and study the therapeutic properties of this system through different characterization techniques and in vitro biological assays. Besides, the materials were activated by neutron capture in a nuclear reactor to produce both 32 P and 89 Sr radioisotopes in order to evaluate the possibility to apply this system for therapeutic purposes.…”