Synthesis and Characterization of Substituted Ethyl 2-(1-aminocyclobutyl)- 5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate Derivatives as Antioxidant Agents

Asha, D.; Malviya, Manish; Chandrappa, S.; Sadashiva, C. T.; Vinaya, K.; Shivaramu, Prasanna D.; Rangappa, Kanchugarakoppal S.

doi:10.2174/157018009789353509

Cited by 3 publications

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“…(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate (1) For the synthesis of the target key intermediate 1 the reaction sequences as reported in our previous article were followed [33]. The synthesis of compounds 3(a-i) is also reported earlier [33]. Treating cyclobutanone with ammonium chloride and sodium cyanide in methanol gave 1-isocyanocyclobutanamine.…”

Section: Synthesis Of Ethyl 2-(1-aminocyclobutyl)-5-mentioning

confidence: 99%

Novel Ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxy-pyrimidine-4-carboxylate Derivatives: Synthesis and Anticancer Activities

Asha¹,

Kavitha²,

Chandrappa³

et al. 2010

JCT

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To explore the anticancer activity of 2, 4, 5, 6-substituted pyrimidines, several ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxy-pyrimidine-4-carboxylate derivatives associated with the different substituted aromatic/aliphatic carboxamidesand sulfonamides were synthesized. Different groups and position on phenyl ring attached to the carboxamideand sulfonamide of the pyrimidine led to two set of compounds. Their chemical structures were confirmed by IR,1H NMR and LC/MS analysis. Cytotoxicity of all the synthesized compounds were examined on human leukemia celllines (K562 and CEM). The preliminary results showed most of the derivatives exhibited good antitumor activity. Compoundwith para chloro substitution among carboxamides and compound with meta dichloro substitution among sulphonamidesexhibited significant antitumor activity with IC50 value of 14.0 μM and 15.0 μM respectively against K562cell line. For comparison among electron donating groups between carboxamides and sulfonamides, compounds withpara tert-butyl substitution were chosen for further studies. Cell cycle analysis suggests that both tert-butyl substitutedcompounds are able to induce apoptosis

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Section: Synthesis Of Ethyl 2-(1-aminocyclobutyl)-5-mentioning

confidence: 99%