Synthesis and characterization of superparamagnetic chitosan–dextran sulfate hydrogels as nano carriers for colon-specific drug delivery

Saboktakin, Mohammad Reza; Tabatabaie, Roya M.; Maharramov, Abel; Рамазанов, М. А.

doi:10.1016/j.carbpol.2010.02.034

Cited by 74 publications

(28 citation statements)

References 17 publications

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“…We observed no significant differences between the groups tested but noted that the average EE was lower for Dose 2 compared to Dose 1 for all GelMA concentrations. On average, the EE of Abraxane ® was lower in 15% GelMA, i.e., below 80%, whereas 5% and 10% GelMA achieved EE above 90%, which is high when compared to other studies [39,[58][59][60][61][62]. To explain the loss of drug following encapsulation, we explored the potential effect of the UV exposure used for crosslinking of the GelMA-DDS on the fluorescence intensity of FITC-labeled Abraxane ® .…”

Section: Groupsmentioning

confidence: 94%

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

et al. 2020

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Hydrogels are excellent candidates for the sustained local delivery of anticancer drugs, as they possess tunable physicochemical characteristics that enable to control drug release kinetics and potentially tackle the problem of systemic side effects in traditional chemotherapeutic delivery. Yet, current systems often involve complicated manufacturing or covalent bonding processes that are not compatible with regulatory or market reality. Here, we developed a novel gelatin methacryloyl (GelMA)-based drug delivery system (GelMA-DDS) for the sustained local delivery of paclitaxel-based Abraxane®, for the prevention of local breast cancer recurrence following mastectomy. GelMA-DDS readily encapsulated Abraxane® with a maximum of 96% encapsulation efficiency. The mechanical properties of the hydrogel system were not affected by drug loading. Tuning of the physical properties, by varying GelMA concentration, allowed tailoring of GelMA-DDS mesh size, where decreasing the GelMA concentration provided overall more sustained cumulative release (significant differences between 5%, 10%, and 15%) with a maximum of 75% over three months of release, identified to be released by diffusion. Additionally, enzymatic degradation, which more readily mimics the in vivo situation, followed a near zero-order rate, with a total release of the cargo at various rates (2–14 h) depending on GelMA concentration. Finally, the results demonstrated that Abraxane® delivery from the hydrogel system led to a dose-dependent reduction of viability, metabolic activity, and live-cell density of triple-negative breast cancer cells in vitro. The GelMA-DDS provides a novel and simple approach for the sustained local administration of anti-cancer drugs for breast cancer recurrence.

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Section: Groupsmentioning

confidence: 94%

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

et al. 2020

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“…The presence of sulfate groups ensures a strong electrostatic interaction of DESU with cationic polymers such as chitosan, and formation of polyelectrolyte complexes (PEC) (Anitha, Deepagan, Divya Rani, Deepthy Menon, Nair, & Jayakumar, 2011;Costalat, David, & Delair, 2014;Delair, 2011). Different nanoformulations of DESU/chitosan PEC have been reported for controlled drug delivery (Anitha et al, 2011;Saboktakin, Tabatabaie, Maharramov, & Ramazanov, 2010;Sarmento, Ribeiro, Veiga, & Ferreira, 2006). It could be expected that DESU as a polymer with strong sulfate groups could preferable adsorb the ATC in a form of flavylium cation from the crude aqueous bilberry extract.…”

Section: Introductionmentioning

confidence: 98%

Complexes of dextran sulfate and anthocyanins from Vaccinium myrtillus: Formation and stability

Klimavičiūtė

Navikaite

Jakštas

et al. 2015

Carbohydrate Polymers

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“…10,12 Such work in cancer has forged a pathway to use magnetic nanoparticles for other medical applications. For example, several studies on model drug-loaded MNPs have been reported, including doxorubicin, [13][14][15][16] 5-aminosalicylic acid, 17 insulin, 18 10-hydroxy camptothecin, 19 gallic acid, 20 folic acid, 21 diclofenac sodium, 22 and dexamethasone. 23 It has been found that superparamagnetic MNPs are predisposed to aggregate due to strong dipole-dipole attractions.…”

mentioning

confidence: 99%

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

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Iron oxide magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of iron salts in sodium hydroxide followed by coating separately with chitosan (CS) and polyethylene glycol (PEG) to form CS-MNPs and PEG-MNPs nanoparticles, respectively. They were then loaded with kojic acid (KA), a pharmacologically bioactive natural compound, to form KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The MNPs and their nanocomposites were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. The powder X-ray diffraction data suggest that all formulations consisted of highly crystalline, pure magnetite Fe 3 O 4 . The Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the presence of both polymers and KA in the nanocomposites. Magnetization curves showed that both nanocomposites (KA-CS-MNPs and KA-PEG-MNPs) were superparamagnetic with saturation magnetizations of 8.1 emu/g and 26.4 emu/g, respectively. The KA drug loading was estimated using ultraviolet–visible spectroscopy, which gave a loading of 12.2% and 8.3% for the KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The release profile of the KA from the nanocomposites followed a pseudo second-order kinetic model. The agar diffusion test was performed to evaluate the antimicrobial activity for both KA-CS-MNPs and KA-PEG-MNPs nanocomposites against a number of microorganisms using two Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus subtilis ) and one Gram-negative ( Salmonella enterica ) species, and showed some antibacterial activity, which could be enhanced in future studies by optimizing drug loading. This study provided evidence for the promise for the further investigation of the possible beneficial biological activities of KA and both KA-CS-MNPs and KA-PEG-MNPs nanocomposites in nanopharmaceutical applications.

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Synthesis and characterization of superparamagnetic chitosan–dextran sulfate hydrogels as nano carriers for colon-specific drug delivery

Cited by 74 publications

References 17 publications

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

Complexes of dextran sulfate and anthocyanins from Vaccinium myrtillus: Formation and stability

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

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