Synthesis and characterization of Tb3+/Gd3+ dual-doped multifunctional hydroxyapatite nanoparticles

Liu, Zhigang; Wang, Qiao; Yao, Shaowei; Yang, Lirong; Yu, Shouwu; Feng, Xianying; Li, Fengfeng

doi:10.1016/j.ceramint.2013.10.070

Cited by 47 publications

(13 citation statements)

References 21 publications

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“…Luminescent CaP based materials generated by doping with rare earth ions have already been studied, because they show several excellent properties such as luminescence under visible‐light excitation, long fluorescence lifetime (up to several milliseconds), high quantum yield, sharp emission peaks, color tuning which depends on the choice of dopants and their combination, and good resistance to photo‐bleaching from the environment . Different lanthanide elements were used to dope CaP; these include terbium, gadolinium, dysprosium, and europium …”

Section: Introductionmentioning

confidence: 99%

Luminescent calcium phosphate bioceramics doped with europium derived from fish industry byproducts

Piccirillo

Adamiano

Tobaldi³

et al. 2017

J Am Ceram Soc

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The recovery of valuable compounds from byproducts is at present a priority topic for social, environmental, and economic reasons. In this work we report for the first time the preparation of luminescent calcium phosphate (CaP) bioceramics from waste codfish bones. Codfish bones were treated in aqueous Eu(NO 3 ) 3 solutions of different concentrations, followed by thermal treatment at either 700°C or 1100°C. The resulting materials consisted of hydroxyapatite (HAp), b-tricalcium phosphate (b-TCP) and a small amount of Eu 2 O 3 . Chemical and structural characterization showed that the Eu ions were successfully introduced into the bones and, hence, in the thermally treated CaP phases obtained from them, although mainly in the b-TCP lattice. Photoluminescence investigation revealed that all the materials are luminescent, with samples treated at 1100°C having more intense luminescence than those prepared at 700°C. In vitro evaluation of cell-materials interaction indicated that all the samples displayed good cytocompatibility toward osteoblast cells. This work demonstrates that a simple and effective process, employing Eu as a dopant, can convert fish industry byproducts into highly valuable luminescent CaP bioceramics, having potential applications in biology and medicine for bio-imaging. K E Y W O R D S b-tricalcium phosphate, calcium phosphates, europium, luminescence, waste valorisation Present address

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Section: Introductionmentioning

confidence: 99%

Luminescent calcium phosphate bioceramics doped with europium derived from fish industry byproducts

Piccirillo

Adamiano

Tobaldi³

et al. 2017

J Am Ceram Soc

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“…The shape of the hysteresis loops reflects the existence of a weak long-range magnetic dipole-dipole interaction as a consequence of the incorporation of Gd 3+ into the HAp matrix. Namely, Gd 3+ has a high magnetic moment due to the isotropic electronic ground state of 8 S 7/2 and the half-filled f-orbit and proton relaxation could occur even under low magnetic fields 52 .…”

Section: Resultsmentioning

confidence: 99%

Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging

Ignjatović

Mančić

Vuković

et al. 2019

Sci Rep

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Taking advantage of the flexibility of the apatite structure, nano-and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE 3+ = Gd, eu, Yb, tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at t ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P6 3 /m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca 2+ with smaller Re 3+ ions at both cation positions. the ftiR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:Re 3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λ ex = 370 nm) due to an increased concentration of defects. the "up"-and the "down"-conversion spectra of HAp:Gd/Yb/tm and HAp:Gd/eu powders showed characteristic transitions of tm 3+ and eu 3+ , respectively. furthermore, in contrast to diamagnetic HAp, all HAp:Re 3+ powders exhibited paramagnetic behavior. cell viability tests of HAp:Gd/Yb/tm and HAp:Gd/eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.

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“…which has been extensively studied as a bone substitute or drug delivery carrier has also shown potential as a contrast agent when substituted with various ions like Gd 3+ , Eu 3+ , Tb 3+ etc., for MRI and fluorescent imaging [8][9][10]. HA nanoparticles are non-toxic and provide flexibility in terms of ion substitutions in the crystal structure.…”

Section: Bioceramics Like Hydroxyapatite (Ha Mineral Component Of Bone)mentioning

confidence: 99%

Silver and Gadolinium Ions Co-substituted Hydroxyapatite Nanoparticles as Bimodal Contrast Agent for Medical Imaging

Madhumathi¹,

Ts²,

T³

et al. 2014

Bioceram Dev Appl

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Developing multimodal contrast agents is an upcoming area and hydroxyapatite nanoparticles substituted with various elements like gadolinium, eurobium etc., seems to be a promising contrast agent, especially for multimodal imaging of bone-tissue interface. A bimodal contrast agent using silver (Ag + ) and gadolinium (Gd 3+ ) ions co-substituted hydroxyapatite nanoparticles has been developed for X-ray and magnetic resonance imaging. Ag + and Gd 3+ ions were co-substituted into hydroxyapatite at various atomic percentages (Ag:Gd=0.25:0.25, 0.25:0.5, 0.25:0.75) using microwave accelerated wet chemical synthesis. Pure as well as Ag + and Gd 3+ ions substituted hydroxyapatite samples were also synthesized for comparison. All samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy etc., and found to be monophasic, nanocrystalline with the substituted ions. These co-substituted hydroxyapatite samples were then tested in different diagnostic modalities such as X-ray, computed tomography imaging and magnetic resonance imaging. Appreciable variation in contrast was observed with different amount of substitutions. All the Ag + and Gd 3+ ions co-substituted hydroxyapatite nanoparticles showed higher contrast in all imaging modalities compared to those substituted with either Ag + or Gd 3+ ions only. Hydroxyapatite sample co-substituted with 0.25Ag and 0.75Gd at. % substitution showed the best bimodal CT-MRI contrast.

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Synthesis and characterization of Tb3+/Gd3+ dual-doped multifunctional hydroxyapatite nanoparticles

Cited by 47 publications

References 21 publications

Luminescent calcium phosphate bioceramics doped with europium derived from fish industry byproducts

Luminescent calcium phosphate bioceramics doped with europium derived from fish industry byproducts

Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging

Silver and Gadolinium Ions Co-substituted Hydroxyapatite Nanoparticles as Bimodal Contrast Agent for Medical Imaging

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