Synthesis and characterization of temperature-sensitive and biodegradable hydrogel based on N-isopropylacrylamide

Yu, Yueqin; Li, Yanshun; Zhu, Chunjing; Liu, Lingxiu

doi:10.2478/s11532-009-0144-6

Cited by 10 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, there are examples of partially degradable polyNIPAM-based hydrogels with degradable crosslinks but nondegradable polymer backbone chains. [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The concern with these hydrogels is a release of long, nondegradable polyNIPAM chains after cleavage of crosslinkers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and fabrication of a degradable poly(N‐isopropyl acrylamide) scaffold for tissue engineering applications

Galperin

Long

Garty

et al. 2012

J Biomedical Materials Res

View full text Add to dashboard Cite

Biodegradable poly(N-isopropyl acrylamide) (poly-NIPAM) hydrogels with controlled molecular weight of the parent polymer and its degradation products were synthesized by atom transfer radical polymerization in the presence of a polycaprolactone-based di-chlorinated macroinitiator and polycaprolactone dimethacrylate. The phase transition temperature, swelling, hydrolytic degradability, and mechanical properties at 25 and 37°C were explored. A cytocompatibility study showed good NIH3T3 cell response over 5 days culture on the surface of the hydrogels, demonstrated by a consistent increase in cell proliferation detected by an Alamar Blue assay. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo-lium bromide] results suggested that the hydrogels and their degradation products in the concentration range of 1–25 mg/ mL were not cytotoxic to NIH3T3 cells. A sphere-templating technique was utilized to fabricate biodegradable polyNIPAM scaffolds with monodisperse, pore size. Scaffolds with pore diameter of 48 ± 6 μm were loaded with A-10 smooth muscle cells and then warmed to 37°C entrapping cells in pores approximately 40 μm in diameter, a size we have found to be optimal for angiogenesis and biointegration. Due to their degradable nature, tunable molecular weight, highly interconnected morphology, thermally controlled monodisperse pore size, and temperature-induced volume expansion–contraction, the polyNIPAM-based scaffolds developed in this work will be valuable in tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and fabrication of a degradable poly(N‐isopropyl acrylamide) scaffold for tissue engineering applications

Galperin

Long

Garty

et al. 2012

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…The VTPP of the C 1 A 1.5 N 9.5 A 0.5 hydrogel is 37.3 ± 0.3 • C. Due to the increase in AM content (Figure 6b), the VPTT of C 1 A 1.5 N 6.5 A 3.5 hydrogel cannot be reached. At a specific temperature (37.3-60 • C), the volume of the two layers of hydrogel can change to different degrees, which will lead to the bending of the hydrogel bilayers [27,33].…”

Section: The Vptt Of the Hydrogelmentioning

confidence: 99%

“…The hydrogel is hydrophilic and can swell in water. When the volume phase transition occurs, the hydrogel exhibits hydrophobic properties with hydrogen bond breaks, and the volume shrinks with the change in the hydrogel structure [ 27 , 28 , 29 , 30 ]. This property of temperature-responsive volume changing plays an essential role in the hydrogel bilayer.…”

Section: Introductionmentioning

confidence: 99%

Smart Hydrogel Bilayers Prepared by Irradiation

Huo

An²,

Chang

et al. 2021

Polymers

View full text Add to dashboard Cite

Environment-responsive hydrogel actuators have attracted tremendous attention due to their intriguing properties. Gamma radiation has been considered as a green cross-linking process for hydrogel synthesis, as toxic cross-linking agents and initiators were not required. In this work, chitosan/agar/P(N-isopropyl acrylamide-co-acrylamide) (CS/agar/P(NIPAM-co-AM)) and CS/agar/Montmorillonite (MMT)/PNIPAM temperature-sensitive hydrogel bilayers were synthesized via gamma radiation at room temperature. The mechanical properties and temperature sensitivity of hydrogels under different agar content and irradiation doses were explored. The enhancement of the mechanical properties of the composite hydrogel can be attributed to the presence of agar and MMT. Due to the different temperature sensitivities provided by the two layers of hydrogel, they can move autonomously and act as a flexible gripper as the temperature changes. Thanks to the antibacterial properties of the hydrogel, their storage time and service life may be improved. The as prepared hydrogel bilayers have potential applications in control devices, soft robots, artificial muscles and other fields.

show abstract

“…In the literature, there are examples of partially degradable polyNIPAM‐based hydrogels with degradable crosslinks but nondegradable polymer backbone chains 34–48. The concern with these hydrogels is a release of long, nondegradable polyNIPAM chains after cleavage of crosslinkers.…”

Section: Introductionmentioning

confidence: 99%

Reaction kinetics of polyureas with acetylated diamine chain extenders

Song

Liu

2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

Diacetyl hexamethylene-diamine (MHAD) and diacetyl m-phenylenediamine (Mm-PDA) were synthesized by acetylating hexamethyene-diamin (HAD) and mphenylenediamine (m-PDA) with glacial acetic acid in presence of phosphoric acid, in order to retard the high reactivity of polyurea. Chemical structures of modified diamine chain extenders were confirmed through FTIR, the determination of the nitrogen content, High resolution ESI-Fourier transform ion cyclotron resonance (ESI-FTICR) mass spectrometry and 1 H-NMR analysis. Polyureas were synthesized via two-step solution process by reaction of 4,4 0 -diphenyl diisocyanate (MDI), amine terminated polyether (Jeffamine D-2000) with different chain extenders. The influence of modified diamine chain extenders on gel time of polyurea was investigated. The gel time was prolonged from 11s to 52s and 13s to 65s respectively. The reaction kinetics of synthesizing polyureas were studied by FTIR. The results showed that extending reaction with MHAD was second order kinetic mechanism, its apparent activation energy was 43.99 kJÁmol À1 ; extending reaction with Mm-PDA reaction was first order, its activation energy was 58.95 kJÁmol À1 .

show abstract

Synthesis and characterization of temperature-sensitive and biodegradable hydrogel based on N-isopropylacrylamide

Cited by 10 publications

References 25 publications

Synthesis and fabrication of a degradable poly(N‐isopropyl acrylamide) scaffold for tissue engineering applications

Synthesis and fabrication of a degradable poly(N‐isopropyl acrylamide) scaffold for tissue engineering applications

Smart Hydrogel Bilayers Prepared by Irradiation

Reaction kinetics of polyureas with acetylated diamine chain extenders

Contact Info

Product

Resources

About