Synthesis and Characterization of the Adducts of Morpholinedithioccarbamate Complexes of Oxovanadium (IV), Nickel(II), and Copper(II) with Piperidine and Morpholine

Sharma, Mousami; Sharma, Anju; Sachar, Renu

doi:10.1155/2012/689501

Cited by 13 publications

(10 citation statements)

References 7 publications

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“…A number of dithiocarbamate adducts have been reported in literature [ 4 , 12 – 18 ] with various geometries such as square planar [ 19 ], octahedral [ 20 , 21 ] and trigonal prismatic [ 22 ]. Interestingly, their pyridine [ 1 , 12 , 13 ], 2,2′-bipyridine [ 13 , 15 ] triphenylphosphine [ 10 ], and 1,10-phenanthroline [ 1 , 15 ] adducts have been reported to possess antifungal properties.…”

Section: Introductionmentioning

confidence: 99%

Mixed Ligand Complexes ofN-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand

Ekennia¹,

Onwudiwe

Ume³

et al. 2015

Bioinorganic Chemistry and Applications

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A series of mixed ligand dithiocarbamate complexes with a general formula [ML2(py)2], where M = Mn(II), Co(II), Ni(II), and Cu(II), py = pyridine, and L = N-methyl-N-phenyl dithiocarbamate have been prepared and characterised by elemental analysis, FTIR and Uv spectroscopy, magnetic moment, and thermogravimetric and conductance analysis. The infrared spectra showed that symmetrical bidentate coordination occurred with the dithiocarbamate moiety through the sulfur atoms, while neutral monodentate coordination occurred through the nitrogen atom for the pyridine molecule in the complexes. The electronic spectra, elemental analysis, and magnetic moment results proved that the complexes adopted octahedral geometry. The conductance measurement showed that the complexes are nonelectrolytes proving their nonionic nature. The compounds were screened for three human pathogenic fungi: Aspergillus flavus, Aspergillus niger, and Candida albicans. The cobalt complex showed the best antifungal activity among the test compounds. Liquid-liquid extractive abilities of the ligand towards copper and nickel ions in different solvent media were investigated. The ligand showed a strong binding affinity towards the metals ions with an extractive efficiency of about 99%.

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Section: Introductionmentioning

confidence: 99%

Mixed Ligand Complexes ofN-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand

Ekennia¹,

Onwudiwe

Ume³

et al. 2015

Bioinorganic Chemistry and Applications

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“…The nickel(II)-K + C 5 H 8 NOS 2 − complex was prepared by adding an aqueous 0.01M nickel (II) chloride (NiCl 2 .6H 2 O; 2.3771 g) solution to potassium morpholine dithiocarbamate (1:2 M ratio) with stirring [11]. Similarly, copper (II)-K + C 5 H 8 NOS 2 − .2H 2 O complex was synthesized using 0.01 M copper sulfate solution (CuSO 4 .5H 2 O; 2.49 g).…”

Section: Methodsmentioning

confidence: 99%

Syntheses, physicochemical characterization, antibacterial studies on potassium morpholine dithiocarbamate nickel (II), copper (II) metal complexes and their ligands

Balakrishnan

Duraisamy

Murugan

et al. 2019

Heliyon

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Organic molecule dithiocarbamate transition metal complexes are novel and very attractive pharmaceutical targets for the management and control of antibiotic resistant bacteria. The direct reaction has synthesized new transition metal nickel (II), copper (II) complexes of potassium morpholine dithiocarbamate (K + C 5 H 8 NOS 2 − ) ligands and characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), as well as NMR physicochemical techniques. Antibacterial bioefficacy of the ligand and its metal complexes has been investigated in vitro on the growth of Gram-positive ( Staphylococcus aureus MTCC 737, Bacillus cereus MTCC 1272) and the Gram-negative ( Listeria monocytogenes MTCC 657, Shigella flexeneri MTCC 1457) bacteria. The obtained electronic spectral bands are characteristic and consistent with the proposed composition of the ligand as well as its metal complexes. It also provides a further example of the bidentate coordination of dithiocarbamate ligands. Absorption peak values of FTIR are characteristic of the ligand as well as dithiocarbamate group molecules and exhibit their metal coordination. NMR 1 H signal variations also correlate with the coordination mediated chemical shifts. Both the metal complexes showed significant antibacterial activity. However, enhanced antimicrobial activity of the ligands than metal complexes against Gram positive and Gram negative bacteria were observed. Thus, further study on this approach could pave a way for the development of dithiocarbamate-metal complex based antibacterial agent.

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“…Dithiocarbamates are organosulfur ligands [1] and can form chelate compounds in monodentate and bidentate mode or can act as bridging ligands [2]. The resonating structure of dithiocarbamate is as shown in Figure 1 [3].…”

Section: Introductionmentioning

confidence: 99%

Biological Applications of Metal Complexes of Dithiocarbamates

Maurya

Bajpai

2022

J. Appl. Sci. Educ.

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Dithiocarbamates are organosulphur ligands and form chelate compounds with metals. Their uses are reported in the field of accelerating vulcanization, pesticide, material science, organic synthesis, etc. Recent research demonstrated the potential of metal complexes of these ligands as good antifungal, antibacterial, and antitumor agents. Dithiocarbamate complexes have also been reported to use as a plasmonic sensor, as an inhibitor of proteasome, and for antioxidant and antileishmanial activity. This brief review presents the biological activities of metal complexes of dithiocarbamate.

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Synthesis and Characterization of the Adducts of Morpholinedithioccarbamate Complexes of Oxovanadium (IV), Nickel(II), and Copper(II) with Piperidine and Morpholine

Cited by 13 publications

References 7 publications

Mixed Ligand Complexes ofN-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand

Mixed Ligand Complexes ofN-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand

Syntheses, physicochemical characterization, antibacterial studies on potassium morpholine dithiocarbamate nickel (II), copper (II) metal complexes and their ligands

Biological Applications of Metal Complexes of Dithiocarbamates

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