Synthesis and characterization of the PEG‐based nonionic surfactants endowed with carboxylic acid moiety at the hydrophobic terminal

Vesicle Formation by l-Cysteine-Derived Unconventional Single-Tailed Amphiphiles in Water: A Fluorescence, Microscopy, and Calorimetric Investigation

“…Again, the incorporation of carboxylic acid moieties into PEG-based nonionic surfactants showing a pHcontrolled miceller system has been reported by Morikawa and coworker. 35 However, to the best of our knowledge, there are only a couple of reports, one on anionic 27 and the other on cationic 28 surfactant from our group, on the surface activity and self-assembly formation of low-molecular-weight amphiphiles formed by coupling of PEG chain to an ionic headgroup, but there is no report so far on zwitterionic surfactants with PEG as hydrophobic tail. Zwitterionic surfactants are attractive candidates for delivery vehicles of pharmaceutical formulations and also for industrial applications owing to their ability to form different assemblies at different pH.…”

Physicochemical Characterization and Self-Assembly Studies on Cationic Surfactants Bearing mPEG Tail

“…Morikawa and co-worker have reported the incorporation of carboxylic acid moieties into PEG-based nonionic surfactant showing a pH-controlled micellar system. 23 Clusters et al have reported that modification of nonionic pluronic surfactants, PEG-poly-(propylene glycol)-PEG, with carboxylic acids at the terminal exhibits pH-dependent phase separation and micellar behavior for the purpose of the removal of metal ion and organic from the wastewater. 24 Although aggregation of PEGs in the presence of salt and at higher temperatures has been reported in the literature, 25 there is no report so far on the room temperature surface activity and self-assembly formation of lowmolecular-weight ionic amphiphiles formed by coupling mPEG with a small anionic or cationic headgroup by stable chemical bond.…”

“…So far, many micelle-forming copolymers of PEG with different hydrophobic blocks, such as poly ( l -amino acids), , diacyl lipids, − etc., have been used to prepare drug loaded micelles by direct entrapment of drug into the micelle core and without covalent attachment of drug molecules to core-forming blocks. Morikawa and co-worker have reported the incorporation of carboxylic acid moieties into PEG-based nonionic surfactant showing a pH-controlled micellar system . Clusters et al have reported that modification of nonionic pluronic surfactants, PEG-poly(propylene glycol)-PEG, with carboxylic acids at the terminal exhibits pH-dependent phase separation and micellar behavior for the purpose of the removal of metal ion and organic from the wastewater .…”

Can molecules with an anionic head and a poly(ethylene glycol) methyl ether tail self-assemble in water? A surface tension, fluorescence probe, light scattering, and transmission electron microscopic investigation

“…5 Morikawa and co-workers have reported the incorporation of carboxylic acid moieties into a PEG-based nonionic surfactant showing a pHcontrolled micellar system. 6 However, to the best of our knowledge, there is no report on the surface activity and self-assembly of lowmolecular-weight ionic amphiphiles formed by coupling of mPEG and a small anionic or cationic headgroup by a stable chemical bond.…”