Synthesis and characterization of thermal-responsive chitin-based polyurethane copolymer as a smart material

Chen, Szu-Hsien; Tsao, Ching-Ting; Chang, Chien Hsin; Wu, Yao‐Ming; Liu, Zhengwei; Lin, Chang‐Ching; Wang, Chih-Kuang; Hsieh, K. H.

doi:10.1016/j.carbpol.2012.01.055

Cited by 31 publications

(11 citation statements)

References 16 publications

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“…The incipient of gel network formation, which is defined by the gelation temperature, is given by the crossover of G′ and G″. [31] The measurement of the gelation temperature showed a good reproducibility. To characterize gel recovery (polymer network restoration after 1000% strain applied for 180 s), viscosity and storage modules (G′) were monitored at constant frequency of 1 Hz with 5% strain (no effect on gel formation) as a function of time.…”

Section: Methodsmentioning

confidence: 99%

PEG-Chitosan Hydrogel with Tunable Stiffness for Study of Drug Response of Breast Cancer Cells

et al. 2016

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Mechanical properties of the extracellular matrix have a profound effect on the behavior of anchorage-dependent cells. However, the mechanisms that define the effects of matrix stiffness on cell behavior remains unclear. Therefore, the development and fabrication of synthetic matrices with well-defined stiffness is invaluable for studying the interactions of cells with their biophysical microenvironment in vitro. We demonstrate a methoxypolyethylene glycol (mPEG)-modified chitosan hydrogel network where hydrogel stiffness can be easily modulated under physiological conditions by adjusting the degree of mPEG grafting onto chitosan (PEGylation). We show that the storage modulus of the hydrogel increases as PEGylation decreases and the gels exhibit instant self-recovery after deformation. Breast cancer cells cultured on the stiffest hydrogels adopt a more malignant phenotype with increased resistance to doxorubicin as compared with cells cultured on tissue culture polystyrene or Matrigel. This work demonstrates the utility of mPEG-modified chitosan hydrogel, with tunable mechanical properties, as an improved replacement of conventional culture system for in vitro characterization of breast cancer cell phenotype and evaluation of cancer therapies.

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Section: Methodsmentioning

confidence: 99%

PEG-Chitosan Hydrogel with Tunable Stiffness for Study of Drug Response of Breast Cancer Cells

et al. 2016

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“…2,12 Hence, the modulation of PU-based hydrogels with PEG improves the biocompatibility, and enables the adjustment of degradability and mechanical properties by varying the molecular mass or concentration of the PEG. 7,13 The ability to design PU-based hydrogels using a biodegradable and biocompatible polymer building block, either natural 2,12,14 or synthetic, 2,12,15,16 is an essential feature in tailoring their biodegradability and biocompatibility. Natural polymers are generally biocompatible, however their poor mechanical properties, fast degradation rates, poor reproducibility and potential immunogenicity restrict their use.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

et al. 2015

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Article:Frydrych, M., Román, S., Green, N.H. et al. (2 more authors) (2015) Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6. 7974 -7987. ISSN 1759-9962 https://doi.org/10.1039/c5py01136a eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.

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“…Finally, the resultant mixture was continuously stirred under magnetic stirring at 75-85°C for 1.5 h. DMF was added at any time to adjust the solid content of the PU to 15 wt.%. Different concentrations (2%, 3%, 4%, 5%, w:w) of the selected active compounds were added into the mixture, and then, the mixture was poured into a plastic dish and placed in 60°C for 12 h to obtain polyurethane-based temperature-sensitive food packaging films (Chen et al, 2012). Ultimately, the resultant films were peeled off and stored in a vacuum desiccator at 25°C before analysis.…”

Section: Preparation Of Tspu Filmsmentioning

confidence: 99%

Temperature‐sensitive polyurethane (TSPU) film incorporated with carvacrol and cinnamyl aldehyde: antimicrobial activity, sustained release kinetics and potential use as food packaging for Cantonese‐style moon cake

Dong

Xiao

et al. 2019

Int J of Food Sci Tech

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Temperature-sensitive polyurethane (TSPU) films incorporated with carvacrol and cinnamyl aldehyde were prepared for the potential use of food packaging. The antimicrobial properties and sustained release kinetics of carvacrol and cinnamyl aldehyde in TSPU film were investigated. Results indicated that cinnamyl aldehyde and carvacrol had favourable antimicrobial properties at relatively low addition ratio. The diffusion and release of carvacrol were linearly related to temperature and its addition ratio. The release rates of carvacrol from TSPU film increased from 0.6% to 2.2% with the increase of addition ratio and temperature. The first-order kinetic equation could be used to describe its diffusion and sustained release process. TSPU films could significantly prolong the shelf life of Cantonese-style moon cakes by effectively inhibiting microbial growth and decreasing lipid oxidation comparing with commonly used polyethylene food packaging. Results obtained in the present work can provide technical guide of sustained release food packaging films with antimicrobial properties.

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Synthesis and characterization of thermal-responsive chitin-based polyurethane copolymer as a smart material

Cited by 31 publications

References 16 publications

PEG-Chitosan Hydrogel with Tunable Stiffness for Study of Drug Response of Breast Cancer Cells

PEG-Chitosan Hydrogel with Tunable Stiffness for Study of Drug Response of Breast Cancer Cells

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

Temperature‐sensitive polyurethane (TSPU) film incorporated with carvacrol and cinnamyl aldehyde: antimicrobial activity, sustained release kinetics and potential use as food packaging for Cantonese‐style moon cake

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