Synthesis and Characterization of Thermosensitive Poly(<i>N</i>‐Vinyl Caprolactam)‐Grafted‐Aminated Alginate Hydrogels

Durkut, Serap; Elçin, Yaşar Murat

doi:10.1002/macp.201900412

Cited by 14 publications

(6 citation statements)

References 42 publications

(59 reference statements)

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“…Durkut et al (2020) characterized in vitro performance of a PNVCL-g-Alg-NH 2 copolymer with cytotoxicity and hemocompatibility assays, culturing human dermal fibroblast. Cell viability increased from ~85% to approximately 95% when aminated alginate proportion was diluted from 1/1 to 1/4 [ 65 ]. Further research is necessary to carry out in vivo investigation.…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…Moreover, copolymerization with PNVCL reduced the water absorption of aminated alginate and enhanced its thermal stability. Biocompatibility studies, including in vitro cytotoxicity and blood compatibility analyses, confirmed the nontoxicity of PNVCL-g-Alg-NH 2 scaffolds and their lack of haemolytic effects [236].…”

Section: Phycocolloids As Potential Drug Delivery Systemmentioning

confidence: 68%

“…The hydrogel exhibited a continuous release of DOX-encapsulated In addition, the temperature-responsive properties of alginate gels offer a wide range of potential applications as smart drug carriers. Durkut et al [236] developed a thermosensitive polymer known as poly(N-vinylcaprolactam)-grafted aminated alginate (PNVCL-g-Alg-NH 2 ), which underwent a phase transition and expansion upon water absorption at approximately 35 • C, making it suitable for physiological temperature conditions. Moreover, copolymerization with PNVCL reduced the water absorption of aminated alginate and enhanced its thermal stability.…”

Section: Phycocolloids As Potential Drug Delivery Systemmentioning

confidence: 99%

Algal Phycocolloids: Bioactivities and Pharmaceutical Applications

Lomartire

Gonçalves

2023

Marine Drugs

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Seaweeds are abundant sources of diverse bioactive compounds with various properties and mechanisms of action. These compounds offer protective effects, high nutritional value, and numerous health benefits. Seaweeds are versatile natural sources of metabolites applicable in the production of healthy food, pharmaceuticals, cosmetics, and fertilizers. Their biological compounds make them promising sources for biotechnological applications. In nature, hydrocolloids are substances which form a gel in the presence of water. They are employed as gelling agents in food, coatings and dressings in pharmaceuticals, stabilizers in biotechnology, and ingredients in cosmetics. Seaweed hydrocolloids are identified in carrageenan, alginate, and agar. Carrageenan has gained significant attention in pharmaceutical formulations and exhibits diverse pharmaceutical properties. Incorporating carrageenan and natural polymers such as chitosan, starch, cellulose, chitin, and alginate. It holds promise for creating biodegradable materials with biomedical applications. Alginate, a natural polysaccharide, is highly valued for wound dressings due to its unique characteristics, including low toxicity, biodegradability, hydrogel formation, prevention of bacterial infections, and maintenance of a moist environment. Agar is widely used in the biomedical field. This review focuses on analysing the therapeutic applications of carrageenan, alginate, and agar based on research highlighting their potential in developing innovative drug delivery systems using seaweed phycocolloids.

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“…However, making thermosensitive PSA is not limited to PNIPAM grafting. Poly( N -vinylcaprolactam)-grafted-aminated alginate (PNVCL- g -Alg-NH 2 ) also shows thermoresponsive features . Moreover, making IPNs based on a PSA and a thermosensitive polymer is another robust method to make PSA-based thermosensitive polymers .…”

Section: Tailor-made Psas For Biomedical Applicationsmentioning

confidence: 99%

Tailor-Made Polysaccharides for Biomedical Applications

Khodadadi Yazdi,

Seidi,

Hejna

et al. 2024

ACS Appl. Bio Mater.

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Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either in their pure form or in blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various biomedical applications by incorporating unique molecular structures and targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, and functionalization, have been explored to control their mechanical properties, electrical conductivity, hydrophilicity, degradability, rheological features, and stimuli-responsiveness. For instance, custom-made PSAs are known for their worldwide biomedical applications in tissue engineering, drug/gene delivery, and regenerative medicine. Furthermore, the remarkable advancements in supramolecular engineering and chemistry have paved the way for mission-oriented biomaterial synthesis and the fabrication of customized biomaterials. These materials can synergistically combine the benefits of biology and chemistry to tackle important biomedical questions. Herein, we categorize and summarize PSAs based on their synthesis methods, and explore the main strategies used to customize their chemical structures. We then highlight various properties of PSAs using practical examples. Lastly, we thoroughly describe the biomedical applications of tailor-made PSAs, along with their current existing challenges and potential future directions.

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Synthesis and Characterization of Thermosensitive Poly(N‐Vinyl Caprolactam)‐Grafted‐Aminated Alginate Hydrogels

Cited by 14 publications

References 42 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Algal Phycocolloids: Bioactivities and Pharmaceutical Applications

Tailor-Made Polysaccharides for Biomedical Applications

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