Synthesis and characterization of transition metal complexes of hydrochloride salt of 3‐chlorobenzaldehyde hydralazine hydrazone: a new class of possible anti‐cariogenic agents
Abstract:A novel hydrazone, formed by the condensation of the hydrochloride salt of hydralazine with 3-chlorobenzaldehyde, and its Co (II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of elemental analyses, conductance measurements, magnetic moments, and spectral (infrared, 1 H NMR, UV-visible, electrospray ionization (ESI) mass) and thermal studies. The bidentate behaviour of the ligand is proposed on the basis of spectral studies. Interestingly, all fo… Show more
“…Hydralazine-based hydrazones [14] and 3-chlorobenzaldehyde-based hydrazones [15] have been evaluated separately for their antibacterial and antifungal activity, and they are found to exhibit excellent activity. But as hydrazones are prone to undergo degradation and bacteria can develop resistance to them, complexation of hydrazones with biocompatible metal ions is useful in this regard for long-term effectiveness [16]. For example, two series of ligands based on the very active 2-pyridylcarboxaldehyde isonicotinoyl hydrazone were synthesized and tested as potent anti-tumor agents [17].…”
“…Hydralazine-based hydrazones [14] and 3-chlorobenzaldehyde-based hydrazones [15] have been evaluated separately for their antibacterial and antifungal activity, and they are found to exhibit excellent activity. But as hydrazones are prone to undergo degradation and bacteria can develop resistance to them, complexation of hydrazones with biocompatible metal ions is useful in this regard for long-term effectiveness [16]. For example, two series of ligands based on the very active 2-pyridylcarboxaldehyde isonicotinoyl hydrazone were synthesized and tested as potent anti-tumor agents [17].…”
“…Hydrazones are a class of compounds which are well known for their antimicrobial activity [4,5]. But as hydrazones are prone to undergo degradation and bacteria can develop resistance to them, complexation of hydrazones with biocompatible metal ions is useful in this regard for long-term effectiveness [6]. In the course of our studies on the chemistry of lanthanide compounds, we have prepared and characterized a number of chelates containing hydrazones as ligands.…”
“…Hydrazones are well known for their antimicrobial activity and they are subject to current research [4,5]. But as hydrazones are prone to undergo degradation and bacteria can develop resistance to them, complexation of hydrazones with biocompatible metal ions is useful in this regard for longterm effectiveness [6]. In the course of our studies on the chemistry of lanthanide compounds, we have prepared and characterized a number of complexes containing hydrazones as ligands.…”
C24H20N10O2Cu, orthorhombic, Aba2 (no. 41), a = 12.2281(16) Å, b = 19.176(3) Å, c = 9.8689(13) Å, V = 2314.1(5) Å3, Z = 4, Rgt(F) = 0.0381, wRref(F2) = 0.0752, T = 296(3) K.
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