Synthesis and characterization of two novel biological-based nano organo solid acids with urea moiety and their catalytic applications in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), coumarin-3-carboxylic acid and cinnamic acid derivatives under mild and green conditions

Abstract

Synthesis and characterization of two novel biological-based nano organo solid acids with urea moiety and their catalytic applications in the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ol), coumarin-3carboxylic acid and cinnamic acid derivatives under mild and green conditions 5

Pd(0)‐guanidine@MCM‐41: a very effective catalyst for rapid production of bis (pyrazolyl)methanes

“…Pyrazoles or pyrazolones [e.g. bis (pyrazolyl)methanes] are a significant category of bioactive drug goals in the pharmaceutical industry that show a variety of biological and medicinal activities, such as anti‐HIV, antiviral, gastric secretion stimulatory, antifilarial, antioxidant, antihypertensive, anticancer, anti‐inflammatory, antimalarial, antidepressant, antimicrobial, antipyretic and antibacterial properties. There are two ways to prepare bis (pyrazolyl)methanes: (i) the one‐pot pseudo five‐component reaction among phenylhydrazine, ethyl acetoacetate and aromatic aldehydes; and (ii) the one‐pot pseudo three‐component reaction between 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐one and aromatic aldehydes.…”

1,10‐Phenanthrolin‐1‐ium Trinitromethanide (1,10‐PHTNM) as a Nano Molten Salt Catalyst With Y‐Aromatic Counter Ion: Applications for Synthesis of Organic Compounds

“…The synthesis of organic compounds include 1,4‐dihydropyrano[2,3‐ c ]pyrazoles, tetrahydrobenzo[ b ]pyran, pyrano[4,3‐ b ]pyrans, bispyrazole, 1 H ‐pyrazolo[3,4‐ b ]quinolones, hexahydroacridine‐1,8‐diones and methylenebis(3‐hydroxy‐5,5‐dimethylcyclohex‐2‐enones) has been considerable attention of organic chemists due to their broad range of pharmaceutical and biological properties include arisugacins, anti‐multidrug‐resistant, anti‐inflammatory, photodynamic therapy, inhibitors of human Chk1 kinase, spasmolytic and anti‐filarial agents . Literature survey shows that various processes and catalysts for the synthesis of these compounds include {[HIM]C(CN) 3 }, {[HMIM]C(CN) 3 },, [nano‐Fe 3 O 4 @SiO 2 @(CH 2 ) 3 ‐Imidazole‐SO 3 H]Cl, 2‐carbamoylhydrazine‐1‐sulfonic acid or carbamoylsulfamic acid, L ‐proline, eggshell (ES)‐supported Cu(OH) 2 nanoribbons, triethylbenzylammonium chloride, [2‐MPyH]OTf, ZnCl 2 , hexadecyltrimethylammonium bromide, phosphomolybdic acid and sodium acetate trihydrate urea …”

“…In continuous of our studies in the synthesis of ILS and MSs with Y‐aromatic counter ions and their application for multi‐component reaction (MCRs), in the current work, 1,10‐phenanthrolin‐1‐ium trinitromethanide (1,10‐PHTNM) was designed, synthesized and fully characterized (Scheme ). The described 1,10‐PHTNM as a novel and efficient proton sponge nano molten slat catalyst was used for the synthesis of a good range of organic compounds include 1,4‐dihydropyrano[2,3‐ c ]pyrazoles, tetrahydrobenzo[ b ]pyran, pyrano[4,3‐ b ]pyrans, bispyrazole, 1 H ‐pyrazolo[3,4‐ b ]quinolones, hexahydroacridine‐1,8‐diones and methylenebis(3‐hydroxy‐5,5‐dimethylcyclohex‐2‐enones) (Schemes and ).…”

Synthetic methods and pharmacological potential of some cinnamic acid analogues particularly against convulsions

“…It is present in free form or in the form of esters (ethyl, cinnamyl, benzyl), in different essential oils, resins, balsams, cinnamon oil, Peru balsum and Tolu balsum etc. Cinnamic acid analogues are very essential intermediates in the biosynthetic pathway of the majority of the aromatic natural compounds and are widely distributed in the plants and possess extensive range of pharmacological activities [1]. In addition, cinnamic acids play vital role in the synthesis of other significant compounds such as cinnamic acid analogues can be converted into vastly essential compounds including styrenes and stilbenes through decarboxylation reaction.…”